The ED-AWARENESS-2 Trial: Preventing Awareness During Mechanical Ventilation

This study, called The ED-AWARENESS-2 Trial, is looking at ways to prevent "awareness with paralysis" (being awake but unable to move) in patients who are on a breathing machine (mechanical ventilation) in the emergency department. Researchers are comparing standard practices for using muscle relaxants (neuromuscular blockers) with an educational program for nurses and doctors. This education focuses on using shorter-acting muscle relaxants like succinylcholine. The goal is to see if this approach reduces the number of patients who experience awareness with paralysis, which will be checked up to 30 days after treatment. You might be able to join if you are 18 or older, on a breathing machine, and receiving a muscle relaxant. The study is currently unclear about its recruitment status.

Study design
This study is a pragmatic, multicenter, stepped wedge cluster randomized trial involving 3090 participants across five sites over three years.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your awareness will be assessed for up to 30 days after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05534243

The ED-AWARENESS-2 Trial

Recruiting
NAAges 18+InterventionalSupportive care
Washington University School of Medicine
~3,090 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:Standard neuromuscular blocker practicesEducation

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The prevention of Awareness with Paralysis, as assessed by the modified Brice questionnaire.
Measured over up to 30 days
Awareness
Mechanical Ventilation
Intubation Complication
PTSD
4 sites across 4 states
Iowa1
Minnesota1
New Jersey1
Washington1
  • Brian Fuller, MD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

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  • The prevention of Awareness with Paralysis, as assessed by the modified Brice questionnaire.up to 30 days

    The modified Brice questionnaire will be used in this trial.