The ED-AWARENESS-2 Trial: Preventing Awareness During Mechanical Ventilation
This study, called The ED-AWARENESS-2 Trial, is looking at ways to prevent "awareness with paralysis" (being awake but unable to move) in patients who are on a breathing machine (mechanical ventilation) in the emergency department. Researchers are comparing standard practices for using muscle relaxants (neuromuscular blockers) with an educational program for nurses and doctors. This education focuses on using shorter-acting muscle relaxants like succinylcholine. The goal is to see if this approach reduces the number of patients who experience awareness with paralysis, which will be checked up to 30 days after treatment. You might be able to join if you are 18 or older, on a breathing machine, and receiving a muscle relaxant. The study is currently unclear about its recruitment status.
- Study design
- This study is a pragmatic, multicenter, stepped wedge cluster randomized trial involving 3090 participants across five sites over three years.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your awareness will be assessed for up to 30 days after treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The ED-AWARENESS-2 Trial
At a glance
Conditions
Where it's being run
4 sites across 4 statesStudy leadership
- Brian Fuller, MD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
Who to contact
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What this trial measures
- The prevention of Awareness with Paralysis, as assessed by the modified Brice questionnaire.up to 30 days
The modified Brice questionnaire will be used in this trial.