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NCT05534425

Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange

Enrolling by Invitation
NAAges 50+InterventionalBasic science
University of California, Los Angeles
~160 participants
Updated 2025-09-04 on ClinicalTrials.gov
What's tested:GenX intergenerational mentoring program

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Concentration of Type I interferon antiviral activity (bioassay International Units / mL)
Measured over 10 months

Conditions

Virus Infection, RNA

Explore related trials

RNA Virus Infections

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Steven Cole, Ph.D. · PRINCIPAL_INVESTIGATOR · Professor of Medicine & Psychiatry
  • Teresa E Seeman, Ph.D. · PRINCIPAL_INVESTIGATOR · Professor of Medicine

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Participating in the GenX intergenerational mentoring program
All GenX mentors \> 50 years of age are eligible to participate in this research
GenX program participation requires:
Reside in neighborhood of GenX schools (South-Central Los Angeles)
Pass basic literacy and cognitive function tests

Exclusion

Any health condition that would put participant at risk by enrollment/participation

What this trial measures

  • Concentration of Type I interferon antiviral activity (bioassay International Units / mL)10 months

    Blood cell production of Type I interferon activity will stimulated by exposure to a fixed dose of model viral protein (TruCulture Resiquimod R848 tubes) and quantifying Type I interferon concentration in the cell culture supernatant fluid using the standard Armstrong bioassay (Armstrong, J.A. Cytopathic effect inhibition assay for interferon: microculture plate assay. Methods in enzymology 78, 381-387 (1981).) Antiviral activity is quantified as International Units of Interferon activity / mL.