Cognitive-Behavioral Therapy and Exercise for Teen Girls at Risk for Type 2 Diabetes

This study is looking for teenage girls, aged 12-17, who are at risk for type 2 diabetes and experiencing symptoms of depression. Researchers want to see if different approaches can help prevent type 2 diabetes. You would participate in either Cognitive-Behavioral Therapy (CBT), which helps you change thinking patterns, exercise training, or a combination of both. The goal is to see if these interventions can reduce insulin resistance (when your body doesn't use insulin effectively), improve mood, and increase physical activity. The study aims to enroll 300 participants, and success will be measured by changes in insulin resistance after one year. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 300 female participants, aged 12-17, who meet specific criteria for insulin resistance and depression.
What's involved
You would participate in 1-hour group sessions weekly for 12 weeks, either CBT, exercise training, or a combination, with home practice assigned.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year to measure insulin resistance.

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NCT05543083

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Recruiting
NAAges 12–17InterventionalPrevention
Colorado State University
~300 participants
Updated 2026-04-22 on ClinicalTrials.gov
What's tested:Cognitive-Behavioral Therapy followed by Exercise TrainingExercise Training followed by Cognitive-Behavioral TherapyCognitive-Behavioral Therapy OnlyExercise Training Only

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Insulin Resistance
Measured over 1-year
Insulin Resistance
Depression
Depressive Disorder
Mood Disorders
Mental Disorder in Adolescence
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Disease
2 sites across 1 states
Colorado2

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Eligibility criteria

Inclusion

Female
Age 12-17 years
Body Mass Index (BMI)\>= 85 for age and sex
Type 2 Diabetes (T2D) first-or second-degree relative
Center for Epidemiologic Studies Depression Scale (CES-D) total score \>=21

Exclusion

T2D/ Type 1 Diabetes (T1D) or any major medical condition (e.g. cardiovascular, renal) that would prohibit the ability to participate in exercise training
Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) conduct disorder, substance abuse/ dependence, obsessive compulsive disorder, panic attacks, post-traumatic stress disorder, anorexia/bulimia, \& schizophrenia
Insulin sensitizers, weight loss medications \& chronic steroids
Structured weight loss treatment or bariatric surgery
Pregnancy, nursing
  • Insulin Resistance1-year

    Homeostatic model assessment of insulin resistance (HOMA-IR) estimated from fasting insulin and glucose as part of oral glucose tolerance testing