The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

{ "Understanding How Diet Affects Energy Use", "This study is looking at how different diets affect the amount of energy your body uses to digest food, called Diet-Induced Thermogenesis (DIT). Researchers want to understand how varying amounts of calories, carbohydrates, protein, and fat impact DIT and overall energy use over 24 hours. You would receive different diets, including fasting, and diets with varying calorie levels (from -50% to +200% of your energy needs) and macronutrient balances. The main goal is to measure changes in DIT over 35 days. This study is for healthy volunteers, aged 18-60, who have not intentionally lost weight recently. The current status of the study is unclear.", "design": "This interventional study plans to enroll 120 healthy volunteers. Participants will receive 8 different diets in a random order.", "commitments": "You would stay in a clinic for about 35 days and eat only the food provided. You will undergo multiple tests during this time.", "compensation": "Not stated in the trial record.", "follow_up": "Your Diet-Induced Thermogenesis will be measured at 35 days.", }

Study design: Not specified.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

Recruiting

NAAges 18–60InterventionalBasic science

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

~120 participants

Updated 2026-08-28 on ClinicalTrials.gov

What's tested:+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fatfasting-50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat+150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat+200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein-25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Diet Induced Thermogenesis

Measured over 35 days

Conditions

Obesity

Normal Physiology

Healthy Volunteers

NCT05545306

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

NIDDK, Phoenix
Phoenix, Arizonastudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

Tomas Cabeza De Baca, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who to contact

Office of Participant Recruitment (NIDDK

[email protected]

(602) 200-5315

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Male or female, aged 18-60 years old

No episodes of intentional weight loss over previous 6 months

Exclusion

Current use of tobacco products that exceed "Very Low Dependence" on the Fagerstrom Test for Nicotine Dependence Tool (score greater than 2)

Diabetes

Endocrine disorders, such as

Pulmonary disorders

Cardiovascular diseases,

Hypertension,

Liver disease,

Renal disease

Abnormal kidney function (eGFR \<60 mL/min/1.73m\^2)

Central nervous system disease:

Cancer:

Infectious disease:

Evidence of alcohol abuse as defined by \> =8-point score on the Alcohol consumption screening AUDIT questionnaire in adults

Current use of illegal drugs such as amphetamines, cocaine, opiates, or heroin; use of marijuana is permitted.

For Females:

i. Pregnancy or lactation by history and urine pregnancy test

ii. Peri- or post-menopause by self-report or irregular menstrual cycle.

Measured weight: greater than or equal to 450 lb. (maximum weight allowed on the DXA scanning tables by the manufacturer).

Inability to speak or read English by self-report.

Inability to provide informed consent

History of psychological conditions including (but not limited to) claustrophobia, clinical depression, bipolar disorders, or forms of mental incapacity that would be incompatible with safe and successful participation in this study

Current use of medications/dietary supplements/alternative therapies known to alter energy metabolism

Inability to consume provided diets due to dietary concerns that will not allow them to consume \>=95% of provided calories.

What this trial measures

Diet Induced Thermogenesis35 days
DIT is calculated from 24h EE during feeding-24h EE during fasting under different caloric loads

Trialytics