A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
This study is comparing two different ways to perform a bilateral lung transplant (transplanting both lungs): "off-pump" lung transplantation and "venoarterial ECMO (VA ECMO)" lung transplantation. Researchers want to see which method leads to fewer cases of severe primary graft dysfunction (PGD), which is when the new lungs don't work well right after surgery. They will also look at survival rates. You might be able to join if you are an adult needing a bilateral lung transplant and meet certain health criteria, such as having a mean pulmonary artery pressure of 35 mmHg or less. The study is currently recruiting 228 participants, but its overall status is unclear.
- Study design
- This interventional study plans to enroll 228 participants to compare two surgical techniques for bilateral lung transplantation.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Researchers will check for primary lung graft dysfunction at 48-72 hours and mortality at 90 days after the transplant.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
At a glance
Conditions
Where it's being run
3 sites across 3 statesStudy leadership
- Mauricio Villavicencio, MD, MBA · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Primary Lung Graft Dysfunction (PGD) grade 348-72 hours
Rate of PGD according to the The International Society for Heart and Lung Transplantation (ISHLT) classification
- Mortality90 days
Death rate of subjects following lung transplantation
- Primary Lung Graft Dysfunction (PGD) grade 3 and Mortality48-72 hours and 90 days
Rate of PGD according to the The International Society for Heart and Lung Transplantation (ISHLT) classification plus the Death rate of subjects following lung transplantation