18F-Fluciclovine PET-MRI for Low-Grade Glioma in Children
This study is looking at whether a special imaging scan, called 18F-Fluciclovine PET-MRI, is helpful and safe for children and young adults (ages 1 to 21) who have low-grade glioma (LGG), a type of brain tumor. You might be able to join if you have LGG confirmed by biopsy (unless you have NF1 and classic appearance) and are about to start treatment. Researchers will compare how the tumor looks on these scans before treatment and then again at 3 months and 1 year after starting treatment, to see if it helps doctors understand how the tumor is responding. The study aims to enroll 30 participants, but its current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 30 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would receive an injection of 18F-Fluciclovine before PET-MRI imaging. Imaging will be done before starting treatment, and then at 3 months and 1 year after starting treatment.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for changes in tumor measurements and imaging results for 1 year after starting treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG
At a glance
Conditions
NCT05555550
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
The Children s Hospital of Philadelphia
Philadelphia, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Mariam Aboian, MD,PhD · PRINCIPAL_INVESTIGATOR · The Children s Hospital of Philadelphia
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Compare change in standardized uptake value parameters (SUVmax and SUVpeak) on metabolic tumor volume in 18F-Fluciclovine PET1 year
To identify change in the standardized uptake value (SUV) parameters (SUVmax, SUVpeak) for the 18F-Fluciclovine PET scan
- Compare changes in pretreatment tumor measurement on MRI in pediatric participants who initiate systemic treatment for LGG1 year
Calculate the change in tumor measurement on MRI