Understanding Cognitive Decline After Ischemic Stroke
This observational study aims to understand why some people experience memory and thinking problems (cognitive decline) after an ischemic stroke. Researchers are investigating if a "leaky" blood-brain barrier (a protective layer around the brain) at the time of stroke is linked to a higher risk of cognitive decline over the next three years. You may be able to join if you've had an acute ischemic stroke confirmed by an MRI scan that included special imaging (perfusion imaging with an exogenous contrast agent). The study will be successful if it shows a clear connection between blood-brain barrier disruption and cognitive decline. The current recruitment status is unclear.
- Study design
- This is an observational study planning to enroll 150 participants. It is not testing a specific treatment.
- What's involved
- Assessments will occur every 6 months for 3 years, which will include telephone-based cognitive assessments.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 3 years after the stroke.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Richard Leigh, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in Cognition (Cognitive Decline)Assessments occur every 6 months for 3 years
Serial telephone-based cognitive assessments will be performed to detect cognitive changes (cognitive decline).