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Pallidal Deep Brain Stimulation for Parkinson's Disease Motor Impairment

This study is looking at how the exact placement of Deep Brain Stimulation (DBS) in a part of the brain called the globus pallidus (GP) affects movement problems in people with Parkinson's disease. Researchers want to understand if targeting specific areas of the GP with DBS can improve motor symptoms that don't respond well to other treatments. You may be able to join if you are 21 to 89 years old, have Parkinson's disease, have already had DBS surgery in either the globus pallidus or subthalamic nucleus, and have existing 7T brain imaging. The study will measure changes in movement resistance after 3 weeks to see if the DBS location is successful in improving motor function. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 24 participants. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures changes in movement resistance at 3 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05557864

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Recruiting
NAAges 21–89InterventionalTreatment
University of Minnesota
~24 participants
Updated 2026-01-26 on ClinicalTrials.gov
What's tested:Deep Brain Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in the combined elastic, viscous and inertial resistance across conditions will be assessed by integrating the resistive torque
Measured over 3 weeks

Conditions

Parkinson's Disease

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Parkinson Disease

NCT05557864

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University Of Minnesota

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Colum MacKinnon, PhD
[email protected]
Email the study team

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Eligibility criteria

Inclusion

diagnosis of idiopathic PD
have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
Existing 7T brain imagery

Exclusion

history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
other significant neurological disorder
history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
post-operative complications or adverse effects

What this trial measures

  • Changes in the combined elastic, viscous and inertial resistance across conditions will be assessed by integrating the resistive torque3 weeks

    Average movement rate and amplitude for each tone rate-movement amplitude interval. The amount of variability in angular displacement and velocity will be calculated using the root mean square of the zero mean signal. The structure of the variability will be calculated using the sample entropy function. In addition, we will quantify the number and duration of movement festination or freezing episodes.