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Studying Electrical Activity in High-Grade Glioma During Surgery

This study is looking at the electrical activity in and around high-grade glioma (a type of aggressive brain tumor, including glioblastoma) during standard surgical treatment. Researchers will use special tools called Intraoperative Electrocorticography (ECOG) to record brain activity and will also take a small tissue biopsy from these recording sites. This helps them understand how tumor cells and brain cells communicate electrically. You might be able to join if you have high-grade glioma that appears on an MRI, or if you have a confirmed diagnosis of high-grade glioma and are having surgery for a recurring tumor. The main goal is to see if there's a link between this electrical activity and where the tumor grows or progresses, which will be checked with MRI scans up to 9 months after surgery. The study aims to enroll 10 participants.

Study design
This is an interventional study, but the phase is not specified. It plans to enroll 10 participants.
What's involved
During standard surgical treatment, you will undergo Intraoperative Electrocorticography (ECOG) and have a small tissue biopsy taken at the recording sites.
Compensation
Not stated in the trial record.
Follow-up
You will have follow-up contrast-enhanced MRI scans for up to 9 months post-surgery to check for tumor progression.

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NCT05565118

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Recruiting
PHASE1Ages 18+InterventionalTreatment
Case Comprehensive Cancer Center
~10 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:Standard Surgical TreatmentIntraoperative Electrocorticography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation between electrical activity and anatomic region of progression based on follow-up contrast-enhanced MRI
Measured over Up to 9 months post surgery

Conditions

High Grade Glioma
Glioblastoma

Explore related trials

Malignant Glioma

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Jennifer Yu, MD, PhD · PRINCIPAL_INVESTIGATOR · Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center

Who to contact

Jennifer Yu, MD, PhD
[email protected]
1-866-223-8100
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants who have the appearance of high-grade glioma (HGG, WHO Grade 3 and 4, including GBM) on MR imaging are allowed to consent and will undergo the procedure if the frozen is consistent with HGG
Participants with a history of histologically-confirmed diagnosis of high- grade glioma that are undergoing resection of a recurrent/progressive tumor that is likely recurrent/progressive high- grade glioma as identified on preoperative MR imaging
Age ≥ 18 years old
Volumetric MRI within 1 month prior to surgery
Karnofsky performance status of 60 or higher
The participant (or legally acceptable representative if applicable) provides written informed consent for the trial.
Participants must be considered appropriate neurosurgical candidates with the following screening/baseline laboratory values within 1 month prior to surgery:
Absolute neutrophil count ≥ 1500/µL
Platelets ≥ 100 000/µL
International normalized ratio (INR) OR prothrombin time (PT) Activated partial thromboplastin time (aPTT) ≤1.5 × Upper limit of normal (ULN) unless participant is receiving anticoagulant therapy as long as PT or aPTT is within therapeutic range of intended use of anticoagulants
Urine or Serum Pregnancy Test = Negative (Not applicable to participants with bilateral oophorectomy and/or hysterectomy or to those participants who are postmenopausal).

Exclusion

Severe co-morbidity that would confer excess risk of surgery as determined by the treating physician.
Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy.
Is pregnant
Coagulopathy or platelet dysfunction that increases the risk of intra and postoperative hemorrhage
Tumor location requiring DE placement/biopsy in eloquent or critical region of the brain (e.g. primary motor and sensory cortices, speech and vision centers, thalamus, basal ganglia, cerebellum, brain stem) as deemed by the neurosurgeon designing the surgical plan

What this trial measures

  • Correlation between electrical activity and anatomic region of progression based on follow-up contrast-enhanced MRIUp to 9 months post surgery

    To describe the pattern of electrical activity (neuronal hyperexcitability) in brain surrounding the enhancing tumor during open surgery in patients with high grade gliomas and its correlation with progression