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Exercise Training for Long COVID

This study is looking at how exercise training, specifically cardiac rehabilitation, can help people with Long COVID (Post-acute Sequelae of SARS-CoV-2 Infection). Researchers want to see if exercise can improve your physical ability and your health-related quality of life. They are also trying to understand the body's responses, like heart and lung function, in people with Long COVID. You might be able to join if you are an adult aged 18 or older with a documented history of COVID-19 and have had Long COVID symptoms for more than 12 weeks. The study aims to enroll 30 participants. The study's success will be measured by changes in your functional capacity and quality of life after 12 weeks of exercise training.

Study design
This is an interventional study with a planned enrollment of 30 participants. The study is investigating an exercise protocol.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes are measured at 12 weeks after starting the exercise training.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05566483

Physiology of Long COVID-19 and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity

Recruiting
NAAges 18+InterventionalTreatment
University of Colorado, Denver
~30 participants
Updated 2025-12-04 on ClinicalTrials.gov
What's tested:Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterizing the impact of exercise training (cardiac rehabilitation) on functional capacity among patients with Long COVID
Measured over 12 weeks
+1 more outcome measured

Conditions

Post-acute Sequelae of SARS-CoV-2 Infection

Explore related trials

Post-Acute Sequelae of COVID-19

NCT05566483

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Colorado Hospital

    Aurora, Coloradono site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

William K Cornwell, III, MD
[email protected]
303-724-2085
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Adults ≥18 years with documented history of COVID-19 infection and symptoms consistent with Long COVID lasting \>12 weeks after diagnosis.

Exclusion

History of cardiovascular/pulmonary disease prior to infection
COVID-related myocardial injury such as evidence of myocarditis
Deep vein thrombosis/pulmonary embolism following COVID-19 infection
Exercise intolerance resulting from conditions that are not related to cardiorespiratory or autonomic factors (e.g. osteoarthritis or other musculoskeletal diseases);
Dependency of supplemental oxygen following COVID infection due to cardiovascular and/or pulmonary complications following acute COVID infection

What this trial measures

  • Characterizing the impact of exercise training (cardiac rehabilitation) on functional capacity among patients with Long COVID12 weeks

    functional capacity as determined by VO2max

  • Characterizing the impact of exercise training (cardiac rehabilitation) on HRqOL among patients with Long COVID12 weeks

    Health-related quality of life (HRqOL) from SF-36 form; all items are scored so that a high score defines a more favorable health state. In addition, each item is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100, respectively.