Back to search results

Lifestyle Interventions for Early-Onset Alzheimer's Disease

This study is looking at how lifestyle changes might help people with early-onset Alzheimer's disease. Researchers are testing two main approaches: computerized cognitive training (like brain games) and Tai Chi-Qi Gong exercise. You could be eligible if you are between 40 and 75 years old, have early-onset Alzheimer's disease (diagnosed as amyloid-positive), are fluent in English, and are generally healthy. The study aims to see if these interventions improve thinking, daily function, and mood. Success would mean participants show better performance on memory and executive function tests after the interventions.

Study design
This interventional study plans to enroll 60 participants. Participants will be randomly assigned to one of two groups: cognitive training plus Tai Chi, or an active control group.
What's involved
Participants will complete cognitive training or brain games for about 45 minutes, 4-5 sessions per week for 14 weeks. Tai Chi-Qi Gong or stretching will be done for 30 minutes, twice a week for 14 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive performance will be checked immediately after the 14-week intervention and again 26 weeks later (about 6 months after treatment).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05573490

Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study

Recruiting
NAAges 40–75InterventionalSupportive care
Indiana University
~60 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Cognitive TrainingTai Chi- Qi GongBrain GamesStretching

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Performance on CANTAB Connect computerized Memory Composite immediately post-intervention, after controlling for baseline performance
Measured over 15-Week Post-Intervention Follow-up
+3 more outcomes measured

Conditions

Alzheimer Disease, Early Onset

Explore related trials

Alzheimer's DiseaseAmyloid

Where it's being run

1 sites across 1 states
Indiana1

Study leadership

  • Dustin B Hammers, PhD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Dustin B Hammers, PhD
[email protected]
3179638557
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Enrolled in the Longitudinal Early-Onset AD Study (LEADS) parent study, and being classified via LEADS consensus criteria as having amyloid-positive Early Onset Alzheimer's Disease
Aged 40-64 years at the time of enrollment into LEADS
Fluent in English
In good general health and absent another neurological disorder
Have a knowledgeable informant.
Have had a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment into LEADS
Have sufficient vision, hearing, comprehension, and manual dexterity to participate in the testing and training program

What this trial measures

  • Performance on CANTAB Connect computerized Memory Composite immediately post-intervention, after controlling for baseline performance15-Week Post-Intervention Follow-up

    CANTAB Connect computerized Memory Composite was selected for its remote assessment of memory, with validation in Alzheimer's Disease samples. This composite will be calculated from Paired Associates Learning, Pattern Recognition Memory, and Verbal Paired Associates subtests, with higher scores reflected better performance.

  • Performance on CANTAB Connect computerized Executive Composite immediately post-intervention, after controlling for baseline performance15-Week Post-Intervention Follow-up

    CANTAB Connect computerized Executive Composite was selected for its remote assessment of executive functioning, with validation in Alzheimer's Disease samples. This composite will be calculated from Stockings of Cambridge, Spatial Working Memory, Rapid Visual Processing, and Match To Sample subtests, with higher scores reflected better performance.

  • Performance on CANTAB Connect computerized Memory Composite 26 weeks after intervention, after controlling for baseline performance40-Week Post-Intervention Follow-up

    CANTAB Connect computerized Memory Composite was selected for its remote assessment of memory, with validation in Alzheimer's Disease samples. This composite will be calculated from Paired Associates Learning, Pattern Recognition Memory, and Verbal Paired Associates subtests, with higher scores reflected better performance.

  • Performance on CANTAB Connect computerized Executive Composite 26 weeks after intervention, after controlling for baseline performance40-Week Post-Intervention Follow-up

    CANTAB Connect computerized Executive Composite was selected for its remote assessment of executive functioning, with validation in Alzheimer's Disease samples. This composite will be calculated from Stockings of Cambridge, Spatial Working Memory, Rapid Visual Processing, and Match To Sample subtests, with higher scores reflected better performance.