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Natural History of Cerebral Palsy Study

This study is looking at how cerebral palsy (CP) develops in children during their first two years of life. Researchers will observe infants who have CP or are at high risk for CP to understand how their motor skills (movement), speech and language, and thinking abilities change over time. The goal is to gather detailed information about CP development to help doctors and therapists provide the best care and support for children with CP. You might be able to join if your child is between 3 and 24 months old and has a diagnosis of CP or is considered at high risk for CP, based on certain medical criteria. This study is observational, meaning there are no specific interventions being tested.

Study design
This is an observational study aiming to enroll 100 participants. It is not randomized or blinded.
What's involved
Infants will be assessed at regular intervals up to 24 months of age, across a variety of childhood development areas.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in motor, speech, language, and cognitive skills up to 24 months of corrected age.

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NCT05576948

Natural History of Cerebral Palsy Prospective Study

Recruiting
Not specifiedAges 3–24Observational
Children's Hospital Medical Center, Cincinnati
~100 participants
Updated 2025-09-25 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Motor skills
Measured over 3 months, 6 months, 9 months, 12 months, 18 months, 24 months (corrected age)
+13 more outcomes measured

Conditions

Cerebral Palsy

Explore related trials

Cerebral Palsy

Where it's being run

1 sites across 1 states
Ohio1

Who to contact

Karen L Harpster, PhD
[email protected]
513-803-3604
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Infants will be included if they have a diagnosis of CP or "at high risk of CP" and under the age of 12 months.
Infants at high risk of CP as defined by any two (any combination) of the following:

Exclusion

Infants with progressive or neurodegenerative disorders or genetic disorders not associated with CP
Infants with other disability diagnoses e.g. Down Syndrome

What this trial measures

  • Change in Motor skills3 months, 6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Peabody: Gross and Fine motor skills

  • Change in Speech and Language skills6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Bayley Scales of Infant and Toddler Development

  • Change in Cognitive skills6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Bayley Scales of Infant and Toddler Development

  • Change in Neurologic assessment3 months, 6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Hammersmith Infant Neurological Examination

  • Change in Musculoskeletal assessment3 months, 6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Modified Tardieu Scale

  • Change in Musculoskeletal assessment9 months, 12 months, 18 months, 24 months (corrected age)

    Australian Spasticity Assessment Scale

  • Change in Musculoskeletal assessment18 months, 24 months corrected age

    Hip X-ray

  • Change in Vision6 months, 9 months, 12 months, 18 months, 24 months (corrected age)

    Previas

  • Vision3 months corrected age

    Ricci

  • Change in Sleep9 months, 12 months, 18 months, 24 months (corrected age)

    Sleep disturbances Scale for Children

  • Change in Feeding skills12 months, 18 months, 24 months (corrected age)

    Dysphagia Disorder Survey

  • Change in Self Care6 months, 12 months, 18 months, 24 months (corrected age)

    Pediatric Evaluation of Disability Inventory Computerized Assessment Test

  • Change in Adaptive Behavior12 months, 18 months, 24 months (corrected age)

    Infant Toddler Social Emotional Assessment

  • Change in Parent Well Being12 months, 18 months, 24 months (corrected age)

    Depression, Anxiety and Stress Scale