Bright Light Therapy for Crohn's Disease and Ulcerative Colitis
This study is looking at whether bright light therapy can help people with Crohn's disease (CD) or ulcerative colitis (UC), which are types of inflammatory bowel disease (IBD). Researchers believe that using a special device called a Bright Light Therapy Retimer in the morning might improve gut health and quality of life. You could be eligible if you are 18 or older, have a confirmed diagnosis of CD or UC, and have some signs of inflammation (like a fecal calprotectin level above 50 or a high CRP). You also need to be on a stable dose of your current IBD medication for at least 12 weeks. The study will measure changes in how easily things pass through your gut (intestinal permeability) and your gut bacteria after 15 weeks.
- Study design
- This is an interventional study with 30 participants, comparing Bright Light Therapy Retimer to a placebo device. It is a randomized crossover trial, meaning participants will likely receive both treatments at different times.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints, including changes in intestinal permeability and microbiota, are measured at 15 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Ali Keshavarzian, M.D. · PRINCIPAL_INVESTIGATOR · Rush University Medical Center
- Garth R Swanson, M.D. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina
Who to contact
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What this trial measures
- Changes in intestinal permeability (% excretion of urinary sucralose)15 weeks
Participants will ingest a sugar cocktail at Visits 2-5 and complete a urine collection. Measurement of urinary sugars is done using gas chromatography is used to calculate intestinal permeability.
- Changes in microbiota will be assessed using shotgun metagene sequencing and total microbial community DNA15 weeks
At all study visits, stool samples will be collected and analyzed using shotgun metagene sequencing and total microbial community DNA will be isolated and processed for microbiome analysis.