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Repetitive Transcranial Magnetic Stimulation for Post-Stroke Fatigue

This study is looking into whether repetitive transcranial magnetic stimulation (rTMS), a type of non-invasive brain stimulation, can help people with fatigue after a stroke. Fatigue is a common problem after a stroke and can make daily activities difficult. You might be able to join if you are between 34 and 80 years old, had a stroke more than six months ago, and experience fatigue. The study will measure how much your fatigue changes using a scale called the Fatigue Severity Scale (FSS) seven days after your last treatment. The study is currently unclear on its recruitment status, but it aims to enroll 60 participants.

Study design
This interventional study plans to enroll 60 participants. It compares active repetitive transcranial magnetic stimulation (rTMS) with a sham (inactive) rTMS treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your fatigue will be measured seven days after your last treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05584124

Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue.

Recruiting
PHASE2Ages 34–80InterventionalTreatment
VA Office of Research and Development
~60 participants
Updated 2026-04-21 on ClinicalTrials.gov
What's tested:High frequency repetitive transcranial magnetic stimulationSham repetitive transcranial magnetic stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Fatigue Severity Scale (FSS) score
Measured over Change from baseline FSS score to 7 days after last treatment

Conditions

Stroke
Stroke, Chronic
Fatigue

Explore related trials

FatigueStroke

Where it's being run

1 sites across 1 states
Georgia1

Study leadership

  • John H Kindred · PRINCIPAL_INVESTIGATOR · Atlanta VA Medical and Rehab Center, Decatur, GA

Who to contact

John H Kindred
[email protected]
(970) 426-9350
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

34 - 80 years of age
more than 6 months post-stroke
Clinically present fatigue

Exclusion

Contraindications to MRI/TMS/rTMS (e.g. implanted metal within the head, history of seizures)
Inability to follow simple three-step instructions
Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe TBI)
Pregnancy
strokes within stimulation sites
Pregnancy
Severe hypertension (resting SBP \> 200, DBP \> 120)

What this trial measures

  • Change in Fatigue Severity Scale (FSS) scoreChange from baseline FSS score to 7 days after last treatment

    The Fatigue Severity Scale (FSS) is a patient reported outcome measure assessing perceived influence of fatigue over the past week. The scale consists of nine questions measured on a 7-point Likert scale (1-7). The FSS' range of scores is from 9 (min) to 63 (max) with lower numbers representing lower/less impact of fatigue.