Exploring New Methods for Dementia Clinical Trials with Donepezil

This study is looking for new ways to run clinical trials for Alzheimer's disease (AD), dementia, and mild cognitive impairment (MCI). It's testing if a combination of cognitive and functional abilities, called "δ" (delta), can better measure how well treatments work. The study also wants to see if information from caregivers can help identify people who might respond best to treatment. You might be able to join if you are 65-100 years old, have AD or MCI, and can walk on your own. The study will use Donepezil, a standard medication, to see its effects on dementia severity. The main goal is to see how Donepezil affects "δ" over 24 weeks.

Study design
This is a double-blind study, meaning neither you nor the study team will know if you're in a specific group. It plans to include 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be checked at baseline, and at weeks 4, 12, and 24 after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05592678

δ in Dementia Clinical Trials

Recruiting
NAAges 65+Interventional
The University of Texas Health Science Center at San Antonio
~200 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:Donepezil

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
dTEL change
Measured over At baseline, and weeks 4, 12 and 24.
Alzheimer's Disease (AD)
Dementia
Cognitive Decline
Mild Cognitivie Impairment (MCI)
1 sites across 1 states
Texas1
  • Donald R. Royall, MD · PRINCIPAL_INVESTIGATOR · University of Texas

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  • dTEL changeAt baseline, and weeks 4, 12 and 24.

    Change in a latent dementia-specific phenotype derived from cognitive assessment.