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Improving Exercise Capacity for Lymphoma and Breast Cancer Patients

This study is testing whether a tailored physical activity program or health workshops can help preserve your exercise ability, heart function, memory, and overall quality of life. You would be assigned to either an exercise program using the Trainerize application, or workshops on topics like nutrition and stress. Researchers will measure your exercise capacity (how much oxygen your body uses during activity), take images of your heart, and ask you to complete questionnaires about your health and cognitive function (memory and thinking skills). The main goal is to see if there's a significant improvement in exercise capacity after 6 months. This study is for people aged 18-85 with Stage I-IV Hodgkin's or non-Hodgkin's lymphoma, or Stage I-III breast cancer, who are receiving certain chemotherapy.

Study design
This interventional study plans to enroll 110 participants who will be randomly assigned to one of two pathways: a physical activity intervention or health workshops.
What's involved
You would participate in either 1-2 exercise sessions per week or health workshops. You would also undergo cardiopulmonary exercise testing, an MRI scan, and complete several questionnaires that take 15-40 minutes each.
Compensation
Not stated in the trial record.
Follow-up
Your exercise capacity will be measured at the beginning of the study and again 6 months after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05595577

Improving Exercise Capacity With a Tailored Physical Activity Intervention

Recruiting
NAAges 18–85InterventionalSupportive care
Wake Forest University Health Sciences
~110 participants
Updated 2026-03-20 on ClinicalTrials.gov
What's tested:Exercise with Trainerize applicationCardiopulmonary exercise testingMRI scanQuality of Life QuestionnairesCognitive and Brain Function QuestionnairesBlood draws

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Peak VO2
Measured over At baseline and 6 months after study intervention

Conditions

Non Hodgkin Lymphoma
Heart; Functional Disturbance
Hodgkin Lymphoma
Quality of Life
Stage I Breast Cancer
Stage II Breast Cancer
Stage III Breast Cancer

Explore related trials

Breast CarcinomaHodgkin's GranulomaNon-Hodgkin Lymphoma

Where it's being run

2 sites across 2 states
North Carolina1
Virginia1

Study leadership

  • William Hundley, MD · PRINCIPAL_INVESTIGATOR · Wake Forest Baptist Comprehensive Cancer Center

Who to contact

Study Coordinator
[email protected]
336-758-3027
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Individuals aged 18- 85 years
Diagnosed with stage I-IV Hodgkin's or non-Hodgkin's lymphoma or stage I-III breast cancer
Expected to receive an anthracycline based chemotherapeutic regimen or other potentially cardiotoxic cancer therapies (e.g. chemotherapy regimens \[anthracyclines, trastuzumab, rituximab\]), immuno-therapies (immune checkpoint inhibitors \[ICI's\]) or radiation (within 8 weeks of completion of radiation).29-31
Ability to speak and understand English
Capacity to walk at least 2 city blocks (\~.2 miles) on a flat surface
Expected survival beyond 6 months.
Must have an assistant that will help perform the home-based testing activities

Exclusion

Uncontrolled hypertension (systolic blood pressure \>190 mm Hg or diastolic blood pressure \>100 mm Hg)
Recent history of alcohol or drug abuse, inflammatory conditions such as lupus or inflammatory bowel disease, or another medical condition that might compromise safety or successful completion (unless approved by the participant's physician and the Principal Investigator) NOTE: In the setting of active inflammation, participation will not be approved. If chronic disease is present and stable as judged by the participant's physician and the PI, participation will be approved.
Contraindications to MRI such as ferromagnetic cerebral aneurysm clips or other intracranial metal, pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices (unless approved by the participant's physician and the Principal Investigator)
Pregnant
Unstable angina
Contraindication for exercise training or testing
Inability to exercise on a treadmill or stationary cycle
Significant ventricular arrhythmias (\>20 PVCs/min due to gating difficulty)
Atrial fibrillation with uncontrolled ventricular response
Acute myocardial infarction within 28 days
Inability to provide informed consent

What this trial measures

  • Change in Peak VO2At baseline and 6 months after study intervention

    An analysis of covariance (ANCOVA) model will be used to assess post-intervention group differences in VO2, adjusted for baseline peak VO2.