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Focused Extracorporeal Shockwave Therapy for Knee Arthritis

This study is exploring a treatment called focused extracorporeal shockwave therapy for people with knee osteoarthritis (OA) and chronic knee pain. This therapy uses high-energy shockwaves directed at specific areas in the knee bone that show damage on an MRI scan, called bone marrow lesions (BMLs). These lesions are often linked to knee pain and worsening OA. The study aims to see how well this non-invasive treatment reduces knee pain. You might be able to join if you are between 30 and 80 years old, have knee OA diagnosed by X-ray, have BMLs on an MRI, and have had knee pain for over two months. The main goal is to measure changes in your knee pain after 12 weeks. The current status of this study is unclear.

Study design
This is an exploratory pilot study with 15 participants to test the effectiveness and safety of focused extracorporeal shockwave therapy.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your knee pain will be measured at 12 weeks after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05596591

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

Recruiting
NAAges 30–80InterventionalTreatment
Kessler Foundation
~15 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Focused extracorporeal shockwave therapy

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in knee pain numerical rating scale scores
Measured over 12 weeks

Conditions

Bone Marrow Edema
Knee Osteoarthritis
Knee Pain Chronic

Explore related trials

Edema of bone marrowOsteoarthritis of kneePain of joint of knee

NCT05596591

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Nathan Hogaboom

    West Orange, New Jerseystudy coordinator listed

    Recruiting

  • New Jersey Regenerative Institute

    Cedar Knolls, New Jerseystudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Nathan Hogaboom, PhD
[email protected]
9733243584
Email the study team

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Eligibility criteria

Exclusion

Presence of metal implants such as implanted pacemaker, metal sutures, metallic protheses (including metal pins and rods, heart valves), presence of shrapnel or iron filings in the eye, magnetic dental implants, cochlear implants, cerebral aneurysm clip, and deep brain stimulator.
Claustrophobia.
The patient has been informed by his/her doctor that it is medically unsafe to receive regular MRI as part of his/her medical care.

What this trial measures

  • Change in knee pain numerical rating scale scores12 weeks

    Twelve-week knee pain intensity will be assessed using NRS. Subjects will be asked to rate their average pain, most severe pain, and least severe pain using an 11-point scale (i.e. 0-10) anchored at the ends by "no pain" and "pain as bad as you can imagine." NRS allows comparison across clinical trials of chronic pain treatment and is recommended as a core outcome measure for chronic pain clinical trials.