Health Behavior Change for Alzheimer's Disease Risk

This study is looking at ways to help middle-aged adults make lasting healthy lifestyle changes to reduce their risk of Alzheimer's disease. It compares two educational programs: "Enhanced Healthy Living Education" and "Basic Healthy Living Education." Both programs involve 24 sessions focused on healthy living. The study aims to see how these programs impact your perceived threat of Alzheimer's disease over 8 weeks. You may be able to join if you are between 45 and 69 years old, have normal thinking abilities, speak English, and have at least two risk factors for Alzheimer's, such as a higher BMI, high blood pressure, or a family history of the disease. The study plans to enroll 40 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 40 participants to compare two different healthy living education programs.
What's involved
You would participate in a 24-session healthy living education program. Your perceived threat of Alzheimer's disease will be measured at the start, 4 weeks, and 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your perceived threat of Alzheimer's disease will be measured up to 8 weeks after the start of the study.

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NCT05599425

Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

UNKNOWN
NAAges 45–69InterventionalPrevention
Rhode Island Hospital
~40 participants
Updated 2024-07-25 on ClinicalTrials.gov
What's tested:Enhanced Healthy Living EducationBasic Healthy Living Education

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Perceived Threat of Alzheimer's Disease Scale
Measured over baseline
+11 more outcomes measured
Alzheimer Disease
1 sites across 1 states
Rhode Island1

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Eligibility criteria

Inclusion

age 45-69 years
normal cognition (Minnesota Cognitive Acuity Scale \> 52)
English language fluency
at least two of the following: i) BMI \> 24.9; ii) systolic blood pressure \> 125 mmHg; iii) LDL cholesterol \> 115 mg/dL; iv) HbA1C \> 6.0%; v) at least one APOE ε4 allele; vi) first-degree relative with AD.

Exclusion

history of serious mental illness (i.e., schizophrenia, bipolar disorder)
history of neurologic or neurodevelopmental disorder
current alcohol or drug use disorder based on self-report
current enrollment in an AD prevention clinical trial.
  • Perceived Threat of Alzheimer's Disease Scalebaseline

    7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat

  • Perceived Threat of Alzheimer's Disease Scale4 weeks

    7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat

  • Perceived Threat of Alzheimer's Disease Scale8 weeks

    7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat

  • Perceived Threat of Alzheimer's Disease Scale12 weeks (treatment endpoint)

    7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat

  • Dementia Awareness Questionnairebaseline

    self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness

  • Dementia Awareness Questionnaire4 weeks

    self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness

  • Dementia Awareness Questionnaire8 weeks

    self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness

  • Dementia Awareness Questionnaire12 weeks

    self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness

  • Generalized Self-Efficacy Scalebaseline

    10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy

  • Generalized Self-Efficacy Scale4 weeks

    10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy

  • Generalized Self-Efficacy Scale8 weeks

    10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy

  • Generalized Self-Efficacy Scale12 weeks

    10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy