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Studying Tumor Tissue to Find New Cancer Treatments

This study aims to collect tissue and blood samples from people with known or suspected cancer. Researchers will compare cancerous tissue to normal tissue to find differences that could lead to new ways to treat cancer. You can join if you are 18 or older and need surgery or a biopsy (a procedure to remove a small piece of tissue for examination) as part of your standard cancer care. The study is looking to enroll 1200 participants. The main goal is to collect these samples during your surgery or biopsy to help identify new targets for future cancer treatments. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will collect information and samples without giving any specific intervention. It plans to enroll 1200 participants.
What's involved
You will be screened, which involves answering health questions by phone or in person. Researchers will also collect information from your medical records, and biological samples will be collected during your surgery or biopsy.
Compensation
Not stated in the trial record.
Follow-up
Samples will be collected at the time of surgery or biopsy. The record does not specify follow-up after this.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05600933

Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment

Enrolling by Invitation
Not specifiedAges 18+Observational
National Cancer Institute (NCI)
~1,200 participants
Updated 2026-05-29 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for premalignant, primary or metastatic solid tumors and hematologic malignancies
Measured over At time of surgery or biopsy

Conditions

Solid Tumors
Hematologic Malignancy
Gastrointestinal Cancer
Liver Cancer
Pancreatic Cancer
Melanoma
Pre-Malignancy
Lung Cancer

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Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Steven A Rosenberg, M.D. · PRINCIPAL_INVESTIGATOR · National Cancer Institute (NCI)

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age \>= 18 years
Willing to undergo serologic testing for HIV, hepatitis B and C
Participants who have a known or suspected cancer that requires surgery or biopsy as a part of the standard of care diagnosis, treatment and/or follow up.
Able and willing to sign an informed consent document.

What this trial measures

  • To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for premalignant, primary or metastatic solid tumors and hematologic malignanciesAt time of surgery or biopsy

    To collect biologic samples from participants undergoing diagnostic or therapeutic interventions for known or suspected cancer for the purpose of identifying novel molecular and biologic therapeutic targets and studying the intratumoral immune landscape.