NCT05601596
Research OutSmarts Endometriosis II Study
Enrolling by Invitation
Not specifiedAges 18–40ObservationalNorthwell HealthInvestigator-initiated
~250 participants
Updated 2026-06-05 on ClinicalTrials.gov
What's tested:Analysis of menstrual blood to predict endometriosis
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
ROSE II: Pilot study to analyze menstrual blood to predict endometriosis
Measured over 2 years
Conditions
Where it's being run
1 sites across 1 statesNew York1
Study leadership
- Peter K Gregersen, MD · PRINCIPAL_INVESTIGATOR · Northwell Health
- Christine N Metz, PhD · PRINCIPAL_INVESTIGATOR · Northwell Health
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
18 to 40 year old menstruating women (continue to get cycles)
More than a light menstrual flow (light flow is soaking less than 1 thin pad or light tampon in 4 hours at peak flow)
Willingness to provide two menstrual samples across two separate menstrual cycles.
Willingness to provide a DNA sample (obtained via menstrual blood or cheek swab)
Consistently Experiencing chronic symptoms of endometriosis\*
Without definitive diagnosis (i.e. pathology report following diagnostic surgery)
Seeking physician evaluation (considered by physician to be a candidate for laproscopic surgery
Willingness to provide at least one of the menstrual samples PRIOR to planned surgery
Surgical and pathological confirmation of endo (or NOT)
Exclusion
under age 18 or over 40 years
Unable/unwilling to provide a menstrual sample
Light menstrual flow (light flow is soaking less than 1 thin pad or light tampon in 4 hours at peak flow)
Diagnosed with endometriosis
More than 1 symptom of endometriosis\*
Report of missed days of work, school, athletic, social and/or other activities due to related pain and discomfort
What this trial measures
- ROSE II: Pilot study to analyze menstrual blood to predict endometriosis2 years
The investigators will utilize single cell RNA sequencing analysis of stromal cells and uNK cells in menstrual effluent in order to define cellular and gene expression phenotypes that have been shown to be highly correlated with the presence of endometriosis