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NCT05604066

Magnetic Resonance Elastography of Myofascial Pain Syndrome

Enrolling by Invitation
NAAges 18+InterventionalDiagnostic
Mayo Clinic
~106 participants
Updated 2025-10-20 on ClinicalTrials.gov
What's tested:Magnetic Resonance (MR) ElastographyMRI structural imaging

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The fascia plane mobility assessed by MR Elastography-based normalized octahedral shear strain (NOSS) measurements
Measured over baseline measures through the study completion (3 years)

Conditions

Myofascial Pain

Explore related trials

Myofascial pain syndrome

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Ziying Yin, Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Absence of a history of chronic pain in the targeted anatomical location (i.e., lower back and low extremities) that had limited activities of daily living or work
A numerical current pain index of less than 0.5 (on a 10-point Visual Analog Scale)
Able to understand the goal of the project and give informed consent.
A history of chronic low back or leg pain (the targeted location will be determined based on the findings in Aim 1) for at least 3 months. (Measured by patient history and physical exam)
A palpable taut band or nodule within the skeletal muscle
Hypersensitive tender spot within the taut band
Recognition of current pain complaint by pressure on the tender nodule/taut band
Painful limit to the full stretch range of motion

Exclusion

Pregnancy or breastfeeding
Any contraindication to an MRI exam
Previous severe/acute back or low extremity injury (including fracture)
Previous back or low extremity surgery
Back and lower limb deformities
Inability to provide consent.
Pregnancy or breastfeeding
Any contraindication to an MRI exam
Previous therapy in the area to be treated within 6 months
Previous severe back or low extremity injury (including fracture) or surgery
Any neurological conditions or active systemic disease (e.g. diabetes, peripheral vascular disease, cancer, rheumatoid arthritis) that impaired sensation/pain perception
Severe osteoarthritis
Skin injuries in the area to be treated
Inability to provide consent.

What this trial measures

  • The fascia plane mobility assessed by MR Elastography-based normalized octahedral shear strain (NOSS) measurementsbaseline measures through the study completion (3 years)

    In response to an external shear force, the fascial layers that surround and separate muscles can deform or slide relative to each other, depending on the fascial plane's mobility. An adhesive interface that experiences a shear force will exhibit shear displacement continuity (i.e., small shear strain) across the interface, while a nonadhesive interface may slip rather than deform, which causes a discontinuity in displacement (i.e., large shear strain). For the targeted fascia plane in low back and legs, the normalized octahedral shear strain (NOSS) will be computed from the shear displacement data measured from MRE to assess the fascia plane mobility. The primary outcome measure is the difference in the fascia plane mobility on MR elastography between patients with myofascial-related pain diseases and healthy controls without myofascial-related pain diseases.