Back to search results

Observational Study on Heart Disease in Testicular Cancer Survivors

This observational study is looking at heart and blood vessel disease (atherosclerotic cardiovascular disease or ASCVD) in men who have survived testicular cancer. Researchers want to understand if certain treatments for testicular cancer, like cisplatin-based chemotherapy (CBCT) or bone marrow transplant (BMT), increase the risk of heart problems later in life. You might be eligible if you are a man aged 18 to 99, are cancer-free, and had testicular cancer treated with CBCT, or CBCT plus BMT, or surgery/surveillance only. The study will assess your lipid profile (fats in your blood) and check for plaque in your coronary arteries (heart arteries) using CT scans. The goal is to find ways to detect heart disease earlier in testicular cancer survivors.

Study design
This is an observational study with a planned enrollment of 150 men. It is not a treatment study but rather looks at health outcomes in different groups of testicular cancer survivors.
What's involved
Participants will undergo an advanced lipid profile blood test, a coronary artery assessment via CT scans, and hormone level testing for hypogonadism.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, lipid profile and coronary plaque assessment, are measured at recruitment and more than 5 years after testicular cancer diagnosis.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05611307

Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors

Recruiting
Not specifiedAges 18–99Observational
Indiana University
~150 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:Lipid profileCoronary artery assessmentHormone levels for hypogonadism

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Lipid profile
Measured over More than 5 years after testicular cancer diagnosis, At recruitment
+1 more outcome measured

Conditions

Testicular Cancer
Survivorship
ASCVD
Coronary Artery Disease
Lipid Disorder
Hypogonadism, Male
Cisplatin Adverse Reaction
Bone Marrow Transplant Complications

Explore related trials

Malignant Testicular Neoplasm

Where it's being run

1 sites across 1 states
Indiana1

Study leadership

  • Noah Richardson, MD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Elizabeth Rowe
[email protected]
317-278-1185
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Patients \>18 years of age
Patients will be recruited only if cancer-free at clinical evaluation time.
For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2)
For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT \& BMT group, Arm 3).
For the comparison cohort, biopsy-proven TC patients who had surgery for or surveillance of their testicular cancer and never received CBCTCBCT or BMT (surgical/surveillance, Arm 1)

Exclusion

Prior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD)
Significant renal disease (GFR\<40)
Allergy to iodinated contrast
Antecedent chemotherapy for another primary cancer.

What this trial measures

  • Lipid profileMore than 5 years after testicular cancer diagnosis, At recruitment

    HDL, LDL, Tg, Cholesterol, Novel Lipid biomarkers using blood draws

  • Coronary plaque assessmentMore than 5 years after testicular cancer diagnosis, At recruitment

    Coronary calcium score, coronary artery anatomy and plaque assessment using CT scans