Improving Medication Adherence in Youth with Kidney or Liver Transplants

This study is looking at whether using a special electronic pillbox and text messages can help young people (ages 13-25) who have had a kidney or liver transplant remember to take their tacrolimus or sirolimus medication. Many young transplant patients struggle to take their anti-rejection medicines regularly, which can lead to serious problems like organ rejection. This study aims to see if this technology can improve how well patients take their medication. Success will be measured by how consistently participants take their doses over 16 months. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 65 participants. It uses a behavioral intervention where participants receive an electronic pillbox.
What's involved
You would use an electronic pillbox for your prescribed medicines for up to 16 months. The research team will teach you how to use this device.
Compensation
Not stated in the trial record.
Follow-up
Your medication adherence will be measured at 16 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05613010

Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant

Recruiting
NAAges 13–25InterventionalTreatment
Johns Hopkins University
~65 participants
Updated 2026-04-13 on ClinicalTrials.gov
What's tested:mHealth Messaging Intervention Group

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Electronically-measured medication adherence (dose taken or not)
Measured over 16 months
Transplant;Failure,Kidney
Transplant; Failure, Liver
Adherence, Medication
Adherence, Patient
Adherence, Treatment
1 sites across 1 states
Maryland1
  • Cyd Eaton, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

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Eligibility criteria

Inclusion

Adolescents and young adults (13-25 years old) who underwent kidney or liver transplantation at least 6 months prior to enrollment
Currently prescribed tacrolimus or sirolimus.

Exclusion

Currently receiving dialysis
Hospitalized for duration of study
Significant developmental or cognitive delay
No access to a mobile device that supports text messaging
Decline to use electronic pill box to monitor daily medication adherence
Non-English speaking
  • Electronically-measured medication adherence (dose taken or not)16 months

    Participants will use an electronic pillbox to assess daily immunosuppressant adherence (tacrolimus or sirolimus), defined as a binary variable: dose taken or not.