This study is comparing two ways to manage severe open tibia (shin bone) fractures that need several surgeries. You might be eligible if you are 18 or older, have a severe open tibia fracture, and need surgery within 72 hours. The study will randomly assign participants to receive either an Antibiotic Cement Bead Pouch (a mix of cement and antibiotics placed in the wound) or Negative Pressure Wound Therapy (NPWT), also known as a Wound VAC. Researchers want to see which method leads to better overall health outcomes, including avoiding amputation or further surgeries, six months after treatment. The study aims to enroll 312 participants, but its current status is unclear.

Study design

This is a multi-center randomized controlled trial planning to enroll 312 participants. Participants will be randomly assigned to one of two treatment groups.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Outcomes will be assessed at 6 weeks, 3 months, and 6 months post-surgery, with the primary outcome measured at 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.