Bone Marrow and Peripheral Blood Immune Responses to Influenza Vaccine
This study is looking at how your body's immune system responds to the seasonal flu vaccine (a licensed, FDA-approved inactivated influenza vaccine). Researchers want to understand how your immune system, specifically certain immune cells called B-cells, react to the vaccine in both your blood and bone marrow. They will track these responses over time to see how long the protection lasts. This study is for healthy adults aged 18 to 64. The goal is to learn more about how the flu vaccine works to protect you from serious illness, as the flu can be very dangerous. The study is considered successful if it helps us better understand the immune response to the flu vaccine.
- Study design
- This is an open-label, single-arm observational study involving 90 participants. It means everyone receives the same treatment, and both you and the study team will know what vaccine you are getting.
- What's involved
- You will receive one dose of the seasonal flu vaccine. You will also provide several blood samples and bone marrow samples over a period of up to one year.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your immune response will be measured for up to one year after vaccination.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Bone Marrow and Peripheral Blood Immune Responses Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Edmund K Waller, MD, PhD · PRINCIPAL_INVESTIGATOR · Emory University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Changes in clonal diversity of B-Cell response to Influenza in bloodStudy Days: 0, 7, 28, 90, 365
Blood samples will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) of Emory University by a skilled clinical research nurse or phlebotomist. Blood samples will be drawn and stored in 8ml CPT tubes. These samples will be maintained at room temperature until they are transported to the laboratory. Clonal diversity of B-Cell response to Influenza in blood will be measured on study days 0, 7, 28, 90, and 365, and compared for changes.
- Changes in clonal diversity of B-Cell response to Influenza in bone marrowStudy Days 0, 28, 365
Bone marrow aspirate specimens will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) by the Principal Investigator. These samples will be collected in 10 ml sodium heparin tubes and labeled with coded subject information. They will be maintained at room temperature until they are transported to the laboratory. Clonal diversity of B-Cell response to Influenza in bone marrow, will be measured on study days 0, 28, and 365, and compared for changes.
- Changes in magnitude of B-Cell response to Influenza in bloodStudy Days: 0, 7, 28, 90, 365
Blood samples will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) of Emory University by a skilled clinical research nurse or phlebotomist. Blood samples will be drawn and stored in 8ml CPT tubes. These samples will be maintained at room temperature until they are transported to the laboratory. Magnitude of B-Cell response to Influenza will be measured on study days 0, 7, 28, 90, and 365, and compared for changes.
- Changes in magnitude of B-Cell response to Influenza in bone marrowStudy Days 0, 28, 365
Bone marrow aspirate specimens will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) by the Principal Investigator. These samples will be collected in 10 ml sodium heparin tubes and labeled with coded subject information. They will be maintained at room temperature until they are transported to the laboratory. Magnitude of B-Cell response to Influenza in bone marrow, will be measured on study days 0, 28, and 365, and compared for changes.
- Changes in persistence of B-Cell response to Influenza in bloodStudy Days: 0, 7, 28, 90, 365
Blood samples will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) of Emory University by a skilled clinical research nurse or phlebotomist. Blood samples will be drawn and stored in 8ml CPT tubes. These samples will be maintained at room temperature until they are transported to the laboratory. Persistence of B-Cell response to Influenza will be measured on study days 0, 7, 28, 90, and 365, and compared for changes. Persistence of B-Cell response to Influenza in blood will be measured on study days 0, 7, 28, 90, and 365, and compared for changes.
- Changes in Bone marrow persistence of B-Cell response to InfluenzaStudy Days 0, 28, 365
Bone marrow aspirate specimens will be drawn, labeled, and logged at the Georgia Clinical \& Translational Science Alliance (CTSA) by the Principal Investigator. These samples will be collected in 10 ml sodium heparin tubes and labeled with coded subject information. They will be maintained at room temperature until they are transported to the laboratory. Persistence of B-Cell response to Influenza in bone marrow, will be measured on study days 0, 28, and 365, and compared for changes.