Wayfinding Intervention for Long-Term Memory Decline and Mild Cognitive Impairment
This study is exploring whether playing special video games can help improve long-term memory in older adults and those with mild cognitive impairment (MCI). Researchers are testing three different types of games: LabyrinthVR software (a virtual reality game), Placebo Games software (other computer games), and Labyrinth Tablet software (a tablet version of the Labyrinth game). The goal is to see if these games can strengthen memory by changing how the brain works. To join, you should be between 60 and 85 years old, speak English fluently, have at least 12 years of education, and have good vision. The study aims to enroll 200 participants, but its current status is unclear.
- Study design
- This interventional study plans to enroll 200 participants. It compares different behavioral interventions, including virtual reality and tablet games.
- What's involved
- You would undergo assessments before and after the training regimen, which includes measuring memory and brain structure. You must also be able to comfortably operate a response box and confirm physical stamina for semi-weekly brisk 30-minute walks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Memory and brain structure are measured immediately after the training regimen is completed.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Wayfinding Intervention and Long-Term Memory
At a glance
Conditions
NCT05625425
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UCSF Mission Bay
San Francisco, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Peter E Wais, PhD · PRINCIPAL_INVESTIGATOR · Neuroscape, Department of Neurology
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- MDT change in mnemonic discriminationbaseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2) providing for a composite score T2-T1
Training-related change in Mnemonic Discrimination Task (MDT) score. MDT tests recognition memory for pairs of common objects (i.e., targets and lures), measuring the variable of the number of images identified as old (studied) or new (novel), and reports a composite index score (0.00 to 1.00) for accuracy post-training (T2) versus baseline (T1)
- TOUR change in recallbaseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2) providing for a composite score T2-T1
Training-related change in recall of number of details in autobiographical memory from a narrated urban tour, such that a composite parametric score shows how many specific details were recalled post-training (T2) versus baseline (T1)
- Volumetric-based brain morphometry for gray and white mattercollected in association with Outcome 1, at baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2)
Structural MRI T1 data will be analyzed in terms of volumetric-based morphometry, measuring the variables of cortical area.
- Task-based cortical functional connectivity associated with mnemonic discrimination capability and in control of sustained visual attentioncollected in association with Outcome 1, at baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2)
functional MRI data will be analyzed in terms of beta-series correlations between co-active cortical regions of interest, measuring the variable of correlation of inter-trial variability across brain regions