Dietary Protein for Muscle Recovery in Heart Failure

This study is looking at whether increasing protein in your diet can help improve muscle mass in people with heart failure. If you have heart failure with reduced ejection fraction (HFrEF), you might experience muscle loss. This trial will compare changes in muscle mass in the arms and legs for people who receive different amounts of protein supplementation. Participants will be randomly assigned to one of three groups: no protein supplement, a low-dose protein supplement (Ensure Original), or a high-dose protein supplement (Ensure Max Protein). The main goal is to see how much muscle mass (appendicular lean mass) changes after 6 months. You may be able to join if you are between 18 and 100 years old and have heart failure with specific criteria, such as a left ventricular ejection fraction (LVEF) of 40% or less, or certain symptoms.

Study design
This is an interventional study that will randomly assign 120 participants to one of three groups to compare different protein supplement levels.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, appendicular lean mass, is measured at the 6-month study visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05627440

A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

Recruiting
NAAges 18+InterventionalSupportive care
Tufts Medical Center
~120 participants
Updated 2025-11-25 on ClinicalTrials.gov
What's tested:Ensure Max ProteinEnsure Original

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Appendicular Lean Mass (ALM)
Measured over 6 month study visit
Heart Failure
Muscle Atrophy

NCT05627440

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Tufts Medical Center

    Boston, Massachusettsstudy coordinator listed

    Recruiting

  • Cleveland Clinic

    Cleveland, Ohiono site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

  • Appendicular Lean Mass (ALM)6 month study visit

    ALM as measured by dual X-ray absorptiometry (DXA)