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CBD/CBD-A for Neuropathic Pain After Spinal Cord Injury

This study is testing if a single oral dose of CBD/CBD-A (a compound found in cannabis) can help reduce neuropathic pain (nerve pain) and change brain activity in people with spinal cord injury (SCI). Researchers will compare the effects of CBD/CBD-A to a placebo (an inactive substance). You may be able to join if you are between 18 and 64 years old, have an SCI, and have experienced neuropathic pain for at least three months. The study aims to see if CBD/CBD-A can decrease pain intensity and unpleasantness, and how it affects your brain's electrical activity. The current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 6 participants.
What's involved
Participants will receive a one-time oral dose of either CBD/CBD-A or a placebo. Pain intensity and brain activity will be measured at baseline, and then again at approximately 3 and 6 hours after the dose.
Compensation
Not stated in the trial record.
Follow-up
Pain intensity will be measured up to 6 hours post-intervention, and brain activity up to 3 hours post-intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05630235

Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI

Completed
PHASE1Ages 18–64InterventionalBasic science
University of Miami
~6 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:CBD/CBD-APlacebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in neuropathic pain intensity or unpleasantness.
Measured over Baseline, approximately 3 hours post intervention, and approximately 6 hours post intervention
+1 more outcome measured

Conditions

SCI - Spinal Cord Injury
Neuropathic Pain

Explore related trials

Neuropathic PainSpinal Cord Injury

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Eva Widerstrom-Noga, PhD, DDS · PRINCIPAL_INVESTIGATOR · University of Miami

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

What this trial measures

  • Change in neuropathic pain intensity or unpleasantness.Baseline, approximately 3 hours post intervention, and approximately 6 hours post intervention

    Assess changes in pain intensity and unpleasantness of the worst neuropathic pain using a numerical rating scale from 0-10 (0 no pain and 10 worst imaginable/unpleasant pain).

  • Change in brain electrocortical activity at rest.Baseline and 3 hours post intervention

    Assess brain electrocortical activity at rest using a 64-channel Biosemi EEG system and conducting EEG power spectrum analysis