PET/MRI Imaging for High Grade Glioma
This study is looking at a new way to use imaging to find active high-grade glioma (a type of brain tumor) in patients aged 10 to 89. You could join if you have newly diagnosed grade III or IV glioma and are receiving standard radiation therapy. The study uses a special PET/MRI scan with O-(2-[18F]Fluoroethyl)-L-tyrosine, [18F]-FET to see if there's still viable tumor after treatment. Researchers want to see if this imaging method can accurately detect viable glioma up to 24 months after your PET/MRI scans. The study is currently recruiting about 20 participants.
- Study design
- This is an interventional study planning to enroll 20 participants. It is a feasibility study, meaning it aims to see if the new imaging approach is practical and useful.
- What's involved
- You would have up to three in-person study visits. The first visit takes up to 2 hours, the second up to 3 hours, and the third up to 6 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- Researchers will assess the detection of viable glioma based on PET up to 24 months after you complete the study PET/MRI visits.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma
At a glance
Conditions
Where it's being run
2 sites across 1 statesStudy leadership
- Jonathan McConathy, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
Who to contact
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What this trial measures
- Detection of viable glioma based on PETUp to 24 months after completing study PET/MRI visits.
The frequency of the detection of viable tumor by FET and/or FMISO based on prespecified standardized uptake values (SUVs) and lesion to normal brain ratios will be measured. We expect to detect viable glioma in at least 25% of patients at this time point.