Imaging Coronary Microvascular Dysfunction (CMD) Study
This study is for people experiencing chest pain (angina) or shortness of breath (dyspnea) who have non-obstructive coronary artery disease (CAD), meaning their heart arteries are not significantly blocked. Researchers are using imaging tests like PET scans and CT angiograms, along with a treadmill exercise test, to better understand and diagnose coronary microvascular dysfunction (CMD). A small group of participants with abnormal PET scan results will also have an invasive procedure called functional angiography. The study aims to see if these methods improve symptoms and quality of life, measured at 3 months. You can join if you are 18 or older and meet specific symptom and heart health criteria, but not if you have reduced heart pumping ability or certain other conditions.
- Study design
- This is an interventional study planning to enroll 60 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo a PET imaging visit, possibly a coronary CT angiogram, and a treadmill exercise stress test. A subset of participants might also have a functional angiography procedure.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your symptoms and quality of life will be measured at 3 months after joining the study.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Imaging Coronary Microvascular Dysfunction (CMD) Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Krishna Patel, MBBS, MSc · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- The Seattle Angina Questionnaire (SAQ)3 months
The Seattle Angina Questionnaire (SAQ) is a 7-item self-administered questionnaire with a 4-week recall period measuring health status in patients with CAD across 3 domains: physical limitation (PL), angina frequency (AF), and quality of life (QoL). Full scale from 0-100, with higher score indicating better health outcome.
- Rose Dyspnea Scale (RDS)3 months
Rose Dyspnea Scale (RDS) is a 4-item questionnaire with a 1-month recall period that assesses patients' level of dyspnea with common activities. Full scores range from 0 to 4, where 0 indicates no dyspnea with activity and 4 indicates significant limitations due to dyspnea. Higher score indicates poorer health outcomes.
- Euro-QOL 5 Dimension Visual Analog Scale (EQ5D-VAS)3 months
Euro-QOL 5 Dimension Visual Analog Scale (EQ5D-VAS) The EQ-5D gives a measure of health-related quality of life. The visual analogue score is a measure of overall self-rated health status with full scale from 0-100. Higher scores indicate better health outcomes.
- Number of ER admissions for chest pain per participant3 months
The number of ER admissions for chest pain per participant.
- Number of use of other invasive or non-invasive diagnostic procedures for CAD3 months
The number of use of other invasive or non-invasive diagnostic procedures for CAD