Bladder Cancer Screening Trial

This study is looking for a better way to screen for bladder cancer, especially for people at higher risk. If you are 50 or older with a history of smoking (at least 15 pack-years) or certain occupational exposures (at least 15 years as a textile worker, painter, or dry cleaner), you might be able to join. Participants will have a urine test (urinalysis) every six months for two years. If certain levels of red blood cells are found in your urine, you might have further tests like a cystoscopy (a procedure to look inside the bladder) or upper tract imaging. The main goal is to see if this screening approach helps find bladder cancer earlier over five years. The current status of this study is unclear, and it plans to enroll 1000 people.

Study design
This is an interventional study, meaning participants will receive a specific intervention (urinalysis screening). It plans to enroll 1000 participants.
What's involved
You would provide urine samples for urinalysis every six months for two years. If your urine test shows certain results, you might undergo additional tests like a cystoscopy or upper tract imaging.
Compensation
Not stated in the trial record.
Follow-up
The study will measure the incidence of bladder cancer at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05646485

Bladder Cancer Screening Trial

Recruiting
NAAges 50+InterventionalScreening
University of Texas Southwestern Medical Center
~1,000 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Urinalysis

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Bladder cancer (BCa)
Measured over 5 years
Bladder Cancer
Urothelial Carcinoma
Hematuria
Smoking Cessation

NCT05646485

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Texas Southwestern Medical Center

    Dallas, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Yair Lotan, MD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center

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Eligibility criteria

Inclusion

Age ≥ 50
Smoking: ≥15 pack-year smoking history
Occupation:≥ 15 years of occupational exposures including: textile worker, painter, dry cleaners

Exclusion

Prior history of bladder, kidney, or prostate cancer
Prior evaluation of micro or gross hematuria within the last 2 years
Do not provide informed consent
  • Incidence of Bladder cancer (BCa)5 years

    Incidence of Bladder cancer is measured by the number of participants who were detected with BCa.