Observational Study of Heart Imaging and Metabolic Interventions

This observational study is looking at how your heart's structure changes after metabolic interventions like bariatric surgery (weight loss surgery) or cardiac rehabilitation (a program to improve heart health). Researchers will use MRI (magnetic resonance imaging) scans to see these changes. The study aims to understand if these changes in your heart's tiny structures are linked to how well your heart works overall. This research could help doctors detect heart disease earlier. You might be able to join if you are over 18 and are a candidate for bariatric surgery, have heart failure, or other cardiovascular diseases. The study plans to enroll 150 participants.

Study design
This is an observational study with two groups: one for bariatric surgery candidates and one for those undergoing cardiac rehabilitation. It is a prospective longitudinal cohort design, meaning participants will be followed over time.
What's involved
If you are in the cardiac rehabilitation group, you will have an MRI at the beginning of a 12-week program. You may also choose to have an MRI of your leg.
Compensation
Not stated in the trial record.
Follow-up
Changes in your heart's microstructure will be measured from the beginning of the study and again 6-12 months later, with measurements taken at 5 years.

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NCT05650307

CV Imaging of Metabolic Interventions

Recruiting
Not specifiedAges 18+Observational
The Cleveland Clinic
~150 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:MRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change of Microstructure from baseline and 6-12months
Measured over 5 years
Bariatric Surgery Candidate
Heart Failure
Cardiovascular Diseases
1 sites across 1 states
Ohio1

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Eligibility criteria

Inclusion

Age \> 18 years of age
Provision of written informed consent
For bariatric surgery group, obesity (BMI\>/=30 kg/m2) and non-obese (BMI \<30 kg/m2; for control group)
For cardiac rehabilitation group, symptomatic cardiovascular disease for patients and no signs of cardiovascular disease for healthy controls

Exclusion

Vulnerable populations will be excluded from this study including Prisoners
Contraindication to CMR imaging to be determined by standard MRI protocols
Decisionally impaired (e.g. dementia or cognitive disability)
  • Change of Microstructure from baseline and 6-12months5 years

    The primary clinical objective of the clinical study is to (1) determine cardiac microstructural phenotypes by cardiac MRI in patients before and after cardiac rehabilitation, or bariatric surgery