Adaptive Trial Scheduling in Naming Treatment for Aphasia

This study is exploring new ways to help people with aphasia, a language disorder often caused by stroke, improve their word-finding abilities. It compares three different behavioral interventions: Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition, and Low-Item Non-Adaptive Spacing Condition. The goal is to see which approach best helps you remember words long-term and use them in everyday life. Researchers will measure your ability to correctly name objects and use those words in different situations before treatment and again three months after treatment. You may be able to join if you are 18 or older, have chronic aphasia from a left hemisphere stroke, and can participate in telehealth sessions. The current recruitment status is unclear.

Study design
This study is designed as a randomized within-subjects crossover study, meaning you will experience all three interventions. It plans to enroll 32 participants.
What's involved
You would participate in 10 weeks of computer-based training for each of the three conditions, with four one-on-one treatment sessions per week. This includes 3-4 (up to 6) assessment sessions, 120 one-on-one treatment sessions, and 24 baseline and follow-up probe sessions over about one year, or up to 18 months, all via telehealth.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be checked at one week, three months, and six months after each treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05653466

Adaptive Trial Scheduling in Naming Treatment for Aphasia

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Pittsburgh
~32 participants
Updated 2025-12-11 on ClinicalTrials.gov
What's tested:Adaptive Spacing ConditionHigh-Item Non-Adaptive Spacing ConditionLow-Item Non-Adaptive Spacing Condition

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects
Measured over Initial assessment (pre-treatment), 3 months post-treatment
+1 more outcome measured
Aphasia
Stroke

NCT05653466

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • William Evans, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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Eligibility criteria

Inclusion

Existing diagnosis of chronic (\>6 months) aphasia subsequent to left hemisphere stroke.
Impaired performance on 2/8 sections of the Comprehensive Aphasia Test.
Must have access to a high-speed internet connection and be able to participate in telehealth.

Exclusion

History of other acquired or progressive neurological disease.
Significant language comprehension impairments
Unmanaged drug / alcohol dependence.
Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.
  • Change in correct responses in Confrontation Naming of Treated and Untreated Pictured ObjectsInitial assessment (pre-treatment), 3 months post-treatment

    Confrontation naming accuracy pictures targeted for each training condition and corresponding untreated items will serve as a primary outcome. Individualized lists for each participant will be selected from a corpus of pictured objects. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.

  • Change in correct responses in Context Generalization of Treated and Untreated Pictured ObjectsInitial assessment (pre-treatment), 3 months post-treatment

    Production of trained words on the context generalization complex scene description task for each training condition and corresponding untreated items will serve as a primary outcome. Words from complex scenes and wordless picture books will be chosen for each participant. These words will consist of a subset of those selected for confrontation naming. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.