Prenatal Aspirin and Postpartum Vascular Function Study

This study is looking at how low-dose aspirin taken during pregnancy might affect blood vessel health after delivery, especially for women who experienced preeclampsia. Preeclampsia is a pregnancy condition that can increase a woman's risk of heart problems later in life. Researchers will use special tests with acetylcholine and endothelin-1 to see how your small blood vessels respond. They are looking for women aged 18-50 who are 12 weeks to 5 years postpartum, including those who had normal pregnancies or preeclampsia, and those who did or did not take low-dose aspirin (LDA) during pregnancy. The study aims to understand how LDA might help prevent long-term blood vessel problems after preeclampsia.

Study design
This is an interventional study planning to enroll 60 women. It is not specified if participants will be randomly assigned to groups or if the study is blinded.
What's involved
You would participate in a single study visit lasting about 4 hours, where tests will be done on your skin's small blood vessels using acetylcholine and endothelin-1.
Compensation
Not stated in the trial record.
Follow-up
Your microvascular function will be measured at the single study visit, which lasts an average of 4 hours.

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NCT05653973

Prenatal Aspirin and Postpartum Vascular Function

Recruiting
EARLY_PHASE1Ages 18–50InterventionalBasic science
Anna Stanhewicz, PhD
~60 participants
Updated 2025-05-31 on ClinicalTrials.gov
What's tested:AcetylcholineEndothelin-1

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
microvascular endothelial function
Measured over at the study visit, an average of 4 hours
+1 more outcome measured
Preeclampsia
Microvascular Function
1 sites across 1 states
Iowa1

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  • microvascular endothelial functionat the study visit, an average of 4 hours

    cutaneous vascular vasodilator response to exogenous acetylcholine perfusion; measured with laser-Doppler flowmetry coupled with intradermal microdialysis delivery of acetylcholine alone or co-infused with L-NAME

  • microvascular endothelin-1-mediated constrictionat the study visit, an average of 4 hours

    cutaneous vascular response to exogenous endothelin-1 perfusion; measured with laser-Doppler flowmetry coupled with intradermal microdialysis delivery of endothelin-1 alone or co-infused with BQ-788 or BQ-123