Prenatal Aspirin and Postpartum Vascular Function Study
This study is looking at how low-dose aspirin taken during pregnancy might affect blood vessel health after delivery, especially for women who experienced preeclampsia. Preeclampsia is a pregnancy condition that can increase a woman's risk of heart problems later in life. Researchers will use special tests with acetylcholine and endothelin-1 to see how your small blood vessels respond. They are looking for women aged 18-50 who are 12 weeks to 5 years postpartum, including those who had normal pregnancies or preeclampsia, and those who did or did not take low-dose aspirin (LDA) during pregnancy. The study aims to understand how LDA might help prevent long-term blood vessel problems after preeclampsia.
- Study design
- This is an interventional study planning to enroll 60 women. It is not specified if participants will be randomly assigned to groups or if the study is blinded.
- What's involved
- You would participate in a single study visit lasting about 4 hours, where tests will be done on your skin's small blood vessels using acetylcholine and endothelin-1.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your microvascular function will be measured at the single study visit, which lasts an average of 4 hours.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Prenatal Aspirin and Postpartum Vascular Function
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- microvascular endothelial functionat the study visit, an average of 4 hours
cutaneous vascular vasodilator response to exogenous acetylcholine perfusion; measured with laser-Doppler flowmetry coupled with intradermal microdialysis delivery of acetylcholine alone or co-infused with L-NAME
- microvascular endothelin-1-mediated constrictionat the study visit, an average of 4 hours
cutaneous vascular response to exogenous endothelin-1 perfusion; measured with laser-Doppler flowmetry coupled with intradermal microdialysis delivery of endothelin-1 alone or co-infused with BQ-788 or BQ-123