Back to search results

Observational Study on Next Generation Cardiac MRI for Heart Conditions

This observational study aims to better understand different heart conditions, including heart failure and ischemic heart disease, by using advanced cardiac MRI (Magnetic Resonance Imaging) technology. Researchers want to see how the tiny structures of the heart (myocardial microstructure) look in people with heart conditions compared to healthy individuals, and how these relate to overall heart function. The study involves receiving an extended clinical cardiac MRI or a research cardiac non-contrast MRI. We are looking for 1000 participants aged 18 and older who have been diagnosed with a cardiovascular disease or are healthy volunteers. The study will measure heart microstructure and function over 20 years to see if the new MRI techniques are effective.

Study design
This is an observational study with a planned enrollment of 1000 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo either an extended clinical cardiac MRI (about one hour total) or a research cardiac non-contrast MRI. The extended MRI includes an additional 25 minutes of research protocol.
Compensation
Not stated in the trial record.
Follow-up
Researchers may review your medical records to follow up on your medical status for up to 5 years after the study starts. Primary endpoints will be measured at 20 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05654272

Development of CIRC Technologies

Recruiting
Not specifiedAges 18+Observational
The Cleveland Clinic
~1,000 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:MRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Myocardial Microstructure (Helix Angle) via Next Generation Cardiac MRI
Measured over 20 years
+1 more outcome measured

Conditions

Cardiovascular Diseases
Heart Failure
Ischemic Heart Disease
Non-ischemic Cardiomyopathy
Valvular Heart Disease
Metabolic Cardiomyopathy
Congenital Heart Disease
Aortic Diseases
Atrial Fibrillation
Ventricular Fibrillation

Explore related trials

Aorta DiseaseAtrial FibrillationCardiovascular DisorderCongenital Heart DiseaseDilated cardiomyopathy due to metabolic disorderGeneralized ischemic myocardial dysfunctionHeart FailureIschemic Heart DiseaseValvular Heart DisorderVentricular Fibrillation

Where it's being run

1 sites across 1 states
Ohio1

Who to contact

CIRC Program Coordinator
[email protected]
216 636-5373
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age ≥ 18 years of age
Provision of written informed consent
If not healthy volunteer, must be diagnosed with cardiovascular disease

Exclusion

Vulnerable populations will be excluded from this study including Prisoners
Other contraindications to CMR imaging to be determined by standard MRI protocols
Decisionally impaired (e.g., dementia or cognitive disability)

What this trial measures

  • Myocardial Microstructure (Helix Angle) via Next Generation Cardiac MRI20 years

    The primary clinical objective of the clinical study is to determine and compare cardiac microstructural phenotypes by cardiac MRI in patients and healthy controls

  • Myocardial Function (Ejection Fraction) via Conventional Cardiac MRI20 years

    Measure cardiac function with conventional cardiac MRI to compare with other primary outcome of microstructure