Imaging Neuroinflammation After COVID-19
This study is looking at brain inflammation in people who have ongoing health issues after a SARS-CoV-2 (COVID-19) infection. It uses a special imaging technique called DPA-714 PET/MRI to visualize and measure inflammation in the brain. Researchers will compare these images with those from healthy volunteers. To join, you must be between 18 and 65 years old and have either had COVID-19 with ongoing symptoms or be a healthy volunteer. You also need to have a specific genetic marker (SNP rs6971) that affects how your body interacts with the imaging agent. The goal is to see if there's a difference in brain inflammation between these groups. The study is currently unclear on its recruitment status.
- Study design
- This is an interventional imaging study planning to enroll 60 participants. It compares individuals with post-acute COVID-19 symptoms to healthy volunteers.
- What's involved
- You would undergo a DPA-714 PET/MRI scan. The primary measurement will be taken at the time of injection/scan and followed up within about 6 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will have a clinical follow-up, usually within 6 weeks of their injection/scan date.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
At a glance
Conditions
NCT05656105
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UAB
Birmingham, Alabamastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jonathan McConathy, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Measurement of regional brain TSPO levels using PET in participants with neurological PASC and healthy volunteersInjection/scan date to clinical follow-up. (Usually within 6 weeks)
PET measures of TSPO binding in brain regions including cerebral cortex, thalami, and brainstem will be quantified in symptomatic study participants and healthy volunteers will be collected and compared between groups