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Understanding APOL1 Genes and Kidney Health in African Americans

This study is looking at the APOL1 gene in African Americans to better understand its connection to kidney disease. Researchers want to find out how common certain APOL1 gene variations are in the Black community. They will also ask participants about their thoughts and feelings regarding genetic testing for APOL1 and how knowing their genetic information might affect their health choices. You can join if you are 18-90 years old and identify as Black/African American. The study aims to understand the frequency of these gene variations and attitudes towards genetic testing, with results expected in one year. This information could help improve care for kidney disease in the future.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to include 600 participants.
What's involved
On the day you enroll, you will have one blood sample taken to check your APOL1 genes. You will also complete a survey about your beliefs on kidney disease, high blood pressure, diabetes, and genetic testing.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study, determining the frequency of APOL1 gene variations, will be measured at one year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05656261

APOL1 Genetic Testing in African Americans

Recruiting
Not specifiedAges 18–90Observational
St. Louis University
~600 participants
Updated 2025-03-20 on ClinicalTrials.gov
What's tested:Assessment of the frequency of APOL-1 renal risk variant in the black population, and evaluating their attitudes about genetic testing and APOL1 genotype via self-administered surveys

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine frequency of APOL1 renal risk variants in black population
Measured over 1 year

Conditions

Genetic Predisposition
Chronic Kidney Diseases
Nephropathy
APOL1 Associated Kidney Disease
Disparities

Explore related trials

APOL1 Associated Kidney DiseaseChronic Kidney Disease

NCT05656261

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • SSM Health Saint Louis University Hospital

    St Louis, Missouristudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Krista Lentine, PhD, MD
[email protected]
314-257-3760
Email the study team

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Eligibility criteria

Inclusion

Ages 18-90
Self-Identified as Black/African American. Race will be self-identified. Patients of African ancestry who identify as multi-racial are also eligible to participate.

Exclusion

Cognitively impaired/unable to provide consent
Terminally ill
Renal replacement therapy (RRT), e.g., (but not limited to) hemodialysis, peritoneal dialysis

What this trial measures

  • Determine frequency of APOL1 renal risk variants in black population1 year

    To assess the frequency and sociodemographic/clinical correlates of APOL1 renal risk variants in a local urban population of Black patients seen in Nephrology, Hypertension, Internal/Family Medicine clinics, or University Hospital.