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Nasal Saline Irrigations After Pituitary Surgery

This study is looking at whether using nasal saline irrigations (like Ocean nasal spray) after surgery for a pituitary tumor helps with recovery. Researchers want to see if this simple step improves your quality of life related to your nose and sinuses. You might be able to join if you are an adult between 19 and 85 years old, are having endoscopic surgery for a pituitary tumor (like a nonfunctioning adenoma, acromegaly, prolactinoma, or Rathke's cleft cyst), and can understand English to complete questionnaires. The main goal is to measure the difference in your sinonasal (nose and sinus) quality of life 12 weeks after surgery. The current status of recruitment is unclear.

Study design
This is a prospective, single-blinded (meaning you won't know if you're getting the saline irrigations or not, but the doctors will), multicenter study. It plans to enroll 140 participants.
What's involved
If you are in the treatment group, you would use saline spray in both nostrils four times daily for the first three days after surgery. The study measures sinonasal quality of life at 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your sinonasal quality of life will be measured 12 weeks after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05659524

Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

Recruiting
NAAges 19–85InterventionalSupportive care
Lori Wood
~140 participants
Updated 2024-04-19 on ClinicalTrials.gov
What's tested:Nasal saline irrigation

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in mean sinonasal quality of life
Measured over 12 weeks

Conditions

Pituitary Tumor

Explore related trials

Pituitary Gland Neoplasm

Where it's being run

2 sites across 2 states
Arizona1
Ohio1

Who to contact

Val Calores
[email protected]
602-406-8772
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

nonfunctioning adenoma
acromegaly
prolactinoma
Rathke's cleft cyst 2. Adults \>18 and \<85 years of age 3. English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales 4. Free of any physical, mental, or medical condition which, in the opinion of the investigator, makes study participation inadvisable 5. Planned binostril surgical approach 6. Either with or without septal flap reconstruction 7. Either with or without septoplasty

What this trial measures

  • Difference in mean sinonasal quality of life12 weeks

    Difference in mean sinonasal quality of life between groups as determined by patient reported Sino-nasal Outcome Test (SNOT-22) scores at 4 weeks. SNOT-22 scoring can be completed during a clinic visit or by phone interview. It is critical that the follow-up times are standardized because symptoms improve with time. A reduction in SNOT-22 composite score is indicative of improvement in symptoms.