Prolonged Exposure Therapy for PTSD in Veterans
This study is investigating how Prolonged Exposure (PE) therapy works for Posttraumatic Stress Disorder (PTSD) in Veterans. Researchers want to understand the changes that happen in the brain and body during and after PE therapy. You may be eligible if you are a Veteran between 18 and 90 years old with a PTSD diagnosis and are interested in PE therapy. The study will measure changes in your PTSD symptoms using a standard assessment called CAPS-5 (Clinician Administered PTSD Scale for DSM-5) at several points during and after treatment to see how effective the therapy is. The study aims to enroll 50 participants, but the current status of recruitment is unclear.
- Study design
- This is an interventional study with a planned enrollment of 50 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would participate in 15 separate visits over 17 weeks, including ten 60-minute PE therapy sessions. During these sessions, devices will record your skin conductance, heart rate, facial muscle activity, and brain activity. You will also complete self-report measures and diagnostic interviews.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your PTSD symptoms will be measured at 1-month after your last treatment session.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mechanisms Underlying the Efficacy of Prolonged Exposure
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Suzanne Pineles · PRINCIPAL_INVESTIGATOR · VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Who to contact
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What this trial measures
- Change from baseline in Clinician Administered PTSD Scale for DSM-5 (CAPS-5)Given during screening session, pre-treatment, mid-treatment (post session 5 in week 5 of treatment), post-treatment (post session 10 in week 10 of treatment), and at 1-month follow up.
The primary clinical outcome, CAPS-5, is the gold standard clinical interview for assessing PTSD severity. In CAPS-5, each of the 20 symptoms of PTSD is rated on a 5-point severity scale ranging from 0 (absent) to 4 (extreme). Total scores range from 0 to 80.