NIMH Rhythms and Blues Study: Understanding Mood and Activity

This observational study, called the NIMH Rhythms and Blues Study, aims to better understand the connection between physical activity, sleep, and mental health. Researchers want to learn more about how movement and mood states are related, especially in people with mood disorders like bipolar disorder and major depression. You could participate if you are between 8 and 70 years old and have a history of a mood disorder, or if you are a healthy spouse or relative of someone with a mood disorder. The study will track your mood and energy levels multiple times a day and use questionnaires to measure your progress every six months. The study is currently recruiting participants.

Study design
This is an observational study with a planned enrollment of 1260 participants, including individuals with mood disorders, their relatives, and spouses.
What's involved
You will participate in the study for up to 2 years. For up to 20 days in a row, at 4 times during the study, you will complete an electronic diary on your smartphone.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for up to 2 years, with standardized questionnaires and clinical rating scales measured every 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05669703

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

Recruiting
Not specifiedAges 8–70Observational
National Institute of Mental Health (NIMH)
~1,260 participants
Updated 2026-08-13 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Scores on standardized questionnaires
Measured over Every 6 months
+2 more outcomes measured
Bipolar Disorder
Major Depression
Migraine
1 sites across 1 states
Maryland1
  • Kathleen R Merikangas, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Mental Health (NIMH)

Opens a ready-to-send draft in your own email app — review before sending.

  • Scores on standardized questionnairesEvery 6 months

    Using standardized scales

  • Subjective mood and energy ratings4x daily

    Using EMA

  • Clinical rating scalesEvery 6 months

    Using standardized scales