Transcranial Direct Current Stimulation for Epilepsy

This study is testing if a treatment called transcranial direct current stimulation (tDCS) can help reduce seizures in people with focal epilepsy, generalized onset epilepsy, or sleep-related epileptic encephalopathy. tDCS involves applying a small electrical current to the scalp using a device called ActivaDose II. Participants will receive either a 0.1 mA or 2.0 mA stimulation daily for two months, with each session lasting about 30 minutes. The main goal is to see if this treatment can lower the number of seizures you experience. To join, you must be at least 6 years old, have at least two seizures per month or a high spike-wave index (a measure from an EEG), and your current seizure medicines haven't fully controlled your seizures. The study is currently unclear on its recruitment status.

Study design
This is an interventional study with 30 planned participants. It is testing two different levels of electrical stimulation (0.1 mA and 2.0 mA).
What's involved
You would receive daily electrical stimulation treatments for two months, with each session lasting about 30 minutes. You would also need to maintain a constant medication schedule during the study.
Compensation
Not stated in the trial record.
Follow-up
The main outcome of the study, seizure count, will be measured at 2 months.

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NCT05673915

Study of Transcranial Direct Current Stimulation to Treat Epilepsy

Recruiting
NAAges 6+InterventionalTreatment
Mayo Clinic
~30 participants
Updated 2026-01-28 on ClinicalTrials.gov
What's tested:ActivaDose II 0.1 mA transcranial direct current stimulation (tDCS)ActivaDose II 2.0 mA transcranial direct current stimulation (tDCS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Seizure Count
Measured over 2 months
Focal Epilepsy
Generalized Onset Epilepsy
Sleep-related Epileptic Encephalopathy
1 sites across 1 states
Minnesota1
  • Brian Lundstrom, MD, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy.
Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%.
Has not had control with at least 2 anti-seizure medicines.
Able to maintain a constant medication for duration of the study (rescue meds allowed).
Subject or legally authorized representative is able to understand consent and keep a seizure diary in English.

Exclusion

A disease likely to progress over course of the study.
Psychogenic non-epileptic seizures.
Suicide attempt or psychiatric hospitalization past 2 years.
A skin condition interfering with scalp electrodes or allergy to silver.
Women will verify not pregnant, and if applicable, have a serum pregnancy test.
Implanted devices (e.g. pacemakers)-except VNS, which is allowed.
  • Seizure Count2 months

    Number of seizures experienced by subjects as determined by self-reported seizure diary