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PRP for Shoulder Osteoarthritis

This study is looking at how effective Platelet-Rich Plasma (PRP) injections are for shoulder osteoarthritis. Researchers are comparing single injections of low-dose PRP, high-dose PRP, and saline (saltwater) to see which works best. You might be able to join if you are 18 to 100 years old, have shoulder pain from osteoarthritis that's at least 5 out of 10, and your pain has lasted for at least 3 months despite other treatments like physical therapy. Success in this study will be measured by changes in your shoulder pain and function using a score called the American Shoulder and Elbow Surgeons (ASES) Shoulder Score, 3 months after the injection. The current status of this study is unclear.

Study design
This interventional study plans to enroll 135 participants. It compares the effects of low-dose PRP, high-dose PRP, and saline injections.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months after their injection to measure their ASES Shoulder Score.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05675527

PRP for Glenohumeral Osteoarthritis

Recruiting
PHASE4Ages 18+InterventionalTreatment
Hospital for Special Surgery, New York
~135 participants
Updated 2025-10-06 on ClinicalTrials.gov
What's tested:Low-dose PRPHigh-dose PRPSaline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
American Shoulder and Elbow Surgeons (ASES) Shoulder Score
Measured over 3 months post-injection

Conditions

Shoulder Osteoarthritis

Explore related trials

Osteoarthritis of glenohumeral joint

NCT05675527

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Hospital for Special Surgery

    New York, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Jonathan Kirschner, MD
[email protected]
646-714-6327
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

18-100 years old
Average NRS pain greater than or equal to 5/10 as a direct result of glenohumeral osteoarthritis (any severity: mild, moderate, or severe) and/or chondral lesion or loss
At least 3 months of pain after onset of symptoms that has failed conservative treatments, including physical therapy
MRI of the affected joint
Transient relief of symptoms after a diagnostic intra-articular injection into the joint
Email address or network access

Exclusion

Inability to hold non-steroidal anti-inflammatory drugs for 2 weeks prior and 1 month after the injection
Prior platelet-rich plasma injection
Steroid injection within 3 months of the initial injection
Hyaluronic acid within 6 months of the initial injection
Involved in workers' compensation or active litigation involving the affected joint
History of Plavix use
Known uncontrolled systemic illness (uncontrolled diabetes, HIV, vasculitis, autoimmune/autoinflammatory disease)
Presence of acute fractures or gross mechanical deformities
Concurrent "uncontrolled" cervical disorders

What this trial measures

  • American Shoulder and Elbow Surgeons (ASES) Shoulder Score3 months post-injection

    The ASES measures pain and function in activities of daily living related to the shoulder. On a 100-point scale, a higher score represents less pain/higher function.