TSC Biosample Repository and Natural History Database

This study is creating a collection of biological samples (like blood, cheek swabs, and tissue) and health information from people with Tuberous Sclerosis Complex (TSC) or Lymphangioleiomyomatosis (LAM). The goal is to help scientists learn more about these conditions, which could lead to new treatments for problems affecting the brain, kidneys, heart, lungs, and skin. You can join if you have been diagnosed with TSC or sporadic LAM. The study aims to collect data and samples from 5000 participants over an average of 15 years to understand the long-term effects of the disease. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will collect information and samples without giving any new treatments. It plans to include 5000 participants.
What's involved
You may choose to provide a blood sample, a cheek swab, or a tissue sample after a medical procedure. Your health information will also be collected over your lifetime.
Compensation
Not stated in the trial record.
Follow-up
Participants' health data and samples will be collected and studied over an average of 15 years.

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NCT05676099

TSC Biosample Repository and Natural History Database

Recruiting
Not specifiedAll AgesObservational
National Tuberous Sclerosis Association
~5,000 participants
Updated 2026-06-24 on ClinicalTrials.gov
What's tested:PhlebotomyBuccal (cheek) swabGenetic TestingTissue donation after routine clinical procedure

At a glance

Recruiting sites
25 of 26 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Natural History data and biosamples including blood, tissue, or other types of biological samples from individuals with TSC
Measured over Average 15 years
Tuberous Sclerosis
Lymphangioleiomyomatosis
26 sites across 17 states
California3
Texas3
Massachusetts2
Missouri2
New York2
Ohio2
Canada2
Alabama1
  • Steve Roberds, PhD · PRINCIPAL_INVESTIGATOR · TSC Alliance

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of tuberous sclerosis complex or lymphangioleiomyomatosis (sporadic LAM).
  • Natural History data and biosamples including blood, tissue, or other types of biological samples from individuals with TSCAverage 15 years

    The purposes of this project are to: * Collect biosamples such as blood, tissue, fluid, or other types of bodily samples from people with TSC. * Collect information about people with TSC over their lifetime.