Comparing Bleeding Reduction Strategies After PCI

This study is looking at two ways to reduce bleeding in patients with coronary artery disease (a condition where blood vessels supplying the heart become narrowed) who have undergone PCI (percutaneous coronary intervention, a procedure to open narrowed arteries). After an initial period of taking aspirin and a potent P2Y12 inhibitor (like prasugrel or ticagrelor), participants will either switch to taking aspirin plus clopidogrel, or they will stop aspirin and continue taking prasugrel or ticagrelor alone. The study aims to see which approach is better at preventing blood clots, measured by thrombus formation after 30 days. You may be able to join if you are 18 or older, have chronic or acute coronary syndrome, and have already had a PCI and been on specific antiplatelet medications for at least 30 or 90 days, depending on your condition. The study plans to enroll 90 participants, but its current recruitment status is unclear.

Study design
This is an interventional study comparing two different drug regimens. It plans to enroll 90 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for thrombus formation, measured at 30 days.

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NCT05681702

Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Florida
~90 participants
Updated 2026-03-09 on ClinicalTrials.gov
What's tested:aspirin plus clopidogrelprasugrel or ticagrelor

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Thrombus formation defined as AUC measured by T-TAS
Measured over 30 days
Coronary Artery Disease
1 sites across 1 states
Florida1
  • Dominick J Angiolillo, MD,PhD · PRINCIPAL_INVESTIGATOR · University of Florida College of Medicine Jacksonville

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  • Thrombus formation defined as AUC measured by T-TAS30 days

    Comparison of the area under the curve (AUC) determined by Total Thrombus formation Analysis System (T-TAS) between potent P2Y12 monotherapy strategy and de-escalation strategy (trough effect).