Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

This study is looking at a behavioral therapy called Acceptance and Commitment Therapy (ACT for SCD) for Black adolescents and young adults (ages 14-21) who have sickle cell disease. The goal is to see if this 6-session group therapy can help with stress related to race and chronic illness, and if it's something people find helpful and easy to participate in. Researchers will measure changes in race-related stress after 12 weeks, and self-efficacy (your belief in your ability to succeed) and internalized stigma (negative feelings about your condition) after 6 months. The study is currently unclear on its recruitment status and plans to enroll 66 participants.

Study design
This is an interventional study, meaning participants will receive a specific therapy. It involves a small group of 30 participants in a non-randomized way, with 8-10 people in each group.
What's involved
Participants will enroll in a 6-session ACT group. The study will measure outcomes at 12 weeks and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after starting the intervention to measure certain outcomes.

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NCT05685368

Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

Recruiting
PHASE1Ages 14–21InterventionalTreatment
Children's Hospital Los Angeles
~66 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:ACT for SCD

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Score on Index of Race-Related Stress (IRRS)-Brief Version
Measured over 12 weeks
+3 more outcomes measured
Race-related Stress
Depression, Anxiety
Quality of Life
Stress Reaction
1 sites across 1 states
California1
  • Xzania Lee, PhD · PRINCIPAL_INVESTIGATOR · Children's Hospital Los Angeles

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  • Total Score on Index of Race-Related Stress (IRRS)-Brief Version12 weeks

    Higher scores on this measure indicate greater race-related stress. The minimum score on this measure is 0 and the maximum is 88.

  • Sickle Cell Self-Efficacy Scale6 mos

    a 9-item, self-administered questionnaire that measures an adult's confidence in managing sickle cell disease (SCD) day-to-day, including pain, emotions, and daily functioning.

  • SCD Health-Related Internalized Stigma Scale6 mos

    an 11-item tool assessing internalized stigma and other factors in sickle cell disease (SCD) patients

  • Transition Readiness Assessment Questionnaire (TRAQ),6 mos

    measure acquisition of transition readiness skills across the five stages of change