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Observational Study on Obesity and Pancreatic Cancer in Minority Populations

This observational study is looking into how obesity might affect pancreatic cancer, especially in African American and Non-Hispanic White individuals. Researchers will collect blood samples, tissue samples (from biopsies or surgery), and review your medical images like CT scans and MRIs. You will also complete a questionnaire about your medical and family history, and lifestyle. The goal is to understand the differences in pancreatic cancer in these groups and how fat tissue might play a role in tumor growth and how well treatments work. This study hopes to find new ways to predict how pancreatic cancer will respond to treatment and identify new targets for therapies. The study plans to enroll 125 participants, but its current status is unclear. You may be able to join if you are 18 or older, self-identify as African American or Non-Hispanic White, and have a suspected or diagnosed pancreatic tumor.

Study design
This is an observational study, meaning researchers will collect information without giving you a specific treatment. It plans to enroll 125 participants.
What's involved
You will have 40 mL of blood drawn, and tissue samples collected during biopsy or surgery if applicable. You will also complete a questionnaire and your routine medical images will be reviewed.
Compensation
Not stated in the trial record.
Follow-up
The study will assess molecular and radiological changes, and biological properties of fat tissue for up to 36 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05687188

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Recruiting
Not specifiedAges 18+Observational
H. Lee Moffitt Cancer Center and Research Institute
~125 participants
Updated 2026-05-26 on ClinicalTrials.gov
What's tested:Blood Sample CollectionTissue Sample CollectionData CollectionMedical Image Collection

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assess molecular and radiological landscape of traditional PDAC tumors in the context of Race/Ethnicity
Measured over at 36 months
+2 more outcomes measured

Conditions

Pancreatic Cancer

Explore related trials

Pancreatic Carcinoma

Where it's being run

2 sites across 2 states
Florida1
Mississippi1

Study leadership

  • Jennifer Permuth, PhD, MS · PRINCIPAL_INVESTIGATOR · Moffitt Cancer Center
  • Mokenge Malafa, MD · PRINCIPAL_INVESTIGATOR · Moffitt Cancer Center

Who to contact

Magdeline D Martin
[email protected]
352-672-0548
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults 18 years of age or older at time of signing informed consent
Patients who self-report as African American, Non-Hispanic White
Patients who present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or the University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor.

Exclusion

Patient under 18 years of age
Has no suspicion or diagnosis of a pancreatic cancer or tumor
Self-reported race/ethnicity other than African American or Non-Hispanic White.

What this trial measures

  • Assess molecular and radiological landscape of traditional PDAC tumors in the context of Race/Ethnicityat 36 months

    Investigators will compare gene prevalence, type and expression of genetic mutations and radiomic features in African American participants vs Non-Hispanic White participants

  • Compare biological properties of Adipose Tissue dysfunctionat 36 months

    Investigators will compare biological properties of Adipose Tissue dysfunction between African American vs Non-Hispanic White participants.

  • Examine the role of Adipose Tissue and PDAC tumor interactions in influencing tumor growth, metastasis, and therapeutic responseat 36 months

    Investigators will compare the biological interactions of Adipose Tissue and PDAC tumor growth between African American vs. Non-Hispanic White participants to develop new and/or targeted drug combinations.