Observational Study of Joint Embolization for Chronic Musculoskeletal Pain

This study is looking at the connection between ongoing (chronic) pain in the shoulder, hip, or knee and unusual blood flow around these joints. If you are a Veteran with chronic pain in one of these joints and mild to moderate joint changes, you might be eligible. Researchers will use a special MRI (magnetic resonance imaging) scan to check blood flow. If abnormal blood flow is found, you may be offered a procedure called joint embolization using Embozene Microspheres to treat your pain. This involves blocking small blood vessels in the joint. If you choose not to have the treatment, you will have another MRI after one year to see how the blood flow changes naturally. The study aims to see how well this treatment works and how blood flow relates to pain over time. Success will be measured by pain scores and MRI results after 3 to 6 months.

Study design
This is an observational study planning to enroll 120 participants. It is not specified if participants are randomized or blinded.
What's involved
You would undergo a perfusion MRI scan and complete surveys about your pain. If you have abnormal blood flow, you might receive a joint embolization procedure. You would have follow-up visits with pain surveys and potentially another MRI at 3 months, 6 months, and 1 year.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 1 year after the initial assessment or intervention, with primary outcomes measured at 3 or 6 months.

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NCT05700682

Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

Recruiting
Not specifiedAges 25–80Observational
Palo Alto Veterans Institute for Research
~120 participants
Updated 2025-08-07 on ClinicalTrials.gov
What's tested:Shoulder/Hip/Knee Embolization with Embozene Microspheres

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary Clinical Outcome (Hip and Knee, Therapeutic Arm Only)
Measured over Score obtained at follow-up visit 6 months after intervention
+2 more outcomes measured
Osteoarthritis, Knee
Osteoarthritis, Hip
Osteo Arthritis Shoulders
Synovitis of Knee
Synovitis/Tenosynovitis - Hip
Synovitis
Pain, Chronic
1 sites across 1 states
California1
  • Sirish Kishore, MD · PRINCIPAL_INVESTIGATOR · VA Palo Alto Health Care System

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  • Primary Clinical Outcome (Hip and Knee, Therapeutic Arm Only)Score obtained at follow-up visit 6 months after intervention

    Composite WOMAC survey score

  • Primary Clinical Outcome (Shoulder, Therapeutic Arm Only)Score obtained at follow-up visit 6 months after intervention

    Composite WORC survey score

  • Primary Imaging Outcome (Therapeutic Arm Only)Research MRI obtained 3 months after intervention

    Quantitative perfusion parameters (Ktrans, mean transit time, fractional extracellular volume, time-to-peak)