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Comparing Artificial Discs for Neck Pain and Myelopathy

This study is comparing two FDA-approved artificial disc implants, the Biomet Zimmer Mobi-C and the Nuvasive Simplify, used in cervical arthroplasty (a neck joint replacement surgery). This surgery replaces a damaged disc in your neck with an artificial one to help with conditions like cervical spondylotic myelopathy (spinal cord compression in the neck) or radiculopathy (pinched nerves). Researchers want to see how well each implant works by looking at things like neck movement, pain, and quality of life before and after surgery. You could be eligible if you are 18-60 years old, have neck pain or nerve issues from a single damaged disc, and haven't found relief from at least six weeks of other treatments. The study status is currently unclear, and it plans to enroll 20 participants.

Study design
This is an observational study comparing two different artificial disc implants. Participants will be matched by age and randomly assigned to receive either the Biomet Zimmer Mobi-C or the Nuvasive Simplify implant.
What's involved
You would have assessments before surgery, and then at 3 months, 6 months, and 1 year after your operation. These assessments will evaluate neck disability, quality of life, pain, and neck range of motion.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 1 year after their surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05701059

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

Recruiting
Not specifiedAges 18–60Observational
University of California, Los Angeles
~20 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:Cervical arthroplastySemi-Constrained Nuvasive SimplifyUnconstrained Biomet Zimmer Mobi-C

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cervical range of motion assessments with VICON
Measured over Will be conducted before surgery (baseline), and 3 months, 6 months, and 1 year post-operation.

Conditions

Cervical Spondylosis With Myelopathy
Cervical Radiculopathy
Cervical Disc Herniation
Degenerative Disc Disease

Explore related trials

Cervical radiculopathyCervical spondylosisIntervertebral Disc Degenerative DisorderProlapsed cervical intervertebral disc

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Daniel C Lu, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles

Who to contact

Daniel C Lu, MD, PhD
[email protected]
(310) 267-2975
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient is skeletally mature and between 18 to 60 years of age
Experiences cervical spondylotic myelopathy and/or radiculopathy typically caused by disc herniation or degenerative disc disease at a single level between C3 to C7
Is unresponsive to at least six weeks of non-surgical conservative care
Has the intention of undergoing cervical arthroplasty for their chief complaint
Signed informed consent form

Exclusion

Patient has had prior cervical spine surgery
Has more than two diseased levels requiring surgery
Has a known allergy to a metal alloy or polyethylene
Is morbidly obese
Has active local or system infection
Has any circumstances or conditions such that their ability to provide informed consent comply with follow-up requirements, or provide self-assessments is compromised (eg: psychiatric disorders, chronic alcohol or substance abuse, etc.)

What this trial measures

  • Cervical range of motion assessments with VICONWill be conducted before surgery (baseline), and 3 months, 6 months, and 1 year post-operation.

    Will measure flexion/extension, lateral bending, rotation, protraction/retraction in degrees. The outcome will reflect any improvement in physiological neck range of motion be patients undergoing this procedure.