Melatonin for Sleep in Resident Trainees During Night Float Shift

This study is looking at whether melatonin can help improve sleep for medical residents who work night shifts. Residents often have trouble sleeping well during and after these shifts. Researchers want to see if taking melatonin, a natural hormone that helps regulate sleep, can increase the total amount of sleep residents get. You might be able to join if you are a resident (Post-Graduate Year 1-5) in anesthesiology, general surgery, obstetrics and gynecology, general medicine, or pediatrics at the University of Virginia. You cannot join if you use other sleep aids, have a diagnosed sleep disorder, or have a pacemaker. The study will measure your total sleep time over two weeks to see if melatonin makes a difference.

Study design
This is an interventional study with 50 participants. You would be randomly assigned to receive either melatonin or a placebo (an inactive substance), and neither you nor the study staff would know which one you are taking.
What's involved
You would take a capsule daily for 12 days and wear a portable EEG monitor (a device that tracks brain waves for sleep) for 12 consecutive days.
Compensation
Not stated in the trial record.
Follow-up
Your total sleep time will be measured over two weeks.

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NCT05701969

Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
University of Virginia
~50 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:MelatoninPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Sleep Time (TST)
Measured over 2 weeks
Sleep Disorders, Circadian Rhythm
1 sites across 1 states
Virginia1
  • Lauren Dunn, MD PHD · PRINCIPAL_INVESTIGATOR · University of Virginia

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Eligibility criteria

Inclusion

Post-Graduate Year 1-5
Current enrollment in anesthesiology, general surgery, obstetrics and gynecology, general medicine, or pediatrics residency at the Unversity of Virginia

Exclusion

Current use of sleep aids
Diagnosed sleep disorder
History of a pacemaker or other medical device.
pregnant or breast-feeding females
Bleeding disorders
Depression
High blood pressure
Seizure disorders
History of transplant on immunosuppression therapy.
  • Total Sleep Time (TST)2 weeks

    Measured in hours and fraction of hours, with a portable electroencephalography monitor ZMachine© Insight+ monitor (General Sleep Corporation, Euclid, OH)