Strengthening Tourette Treatment Options Using TMS to Improve CBIT
This study is looking at how repetitive transcranial magnetic stimulation (rTMS) might help adults with Tourette Syndrome when combined with comprehensive behavioral intervention for tics (CBIT). Participants will be adults aged 18 to 100 with moderate tic severity. You would receive either active rTMS or a sham (inactive) rTMS, followed by eight CBIT sessions. Researchers want to see if rTMS can make CBIT more effective at reducing tic frequency and severity. The study aims to enroll 20 participants, but its current status is unclear.
- Study design
- This is a double-blind, randomized, controlled pilot study. It plans to enroll 20 participants.
- What's involved
- Participants will receive eight CBIT sessions after either active or sham rTMS. The study will measure tic severity for about 3 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your tic severity will be measured through study completion, which averages 3 months.
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Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jessica Frey, MD · PRINCIPAL_INVESTIGATOR · WVU RNI
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Yale Global Tic Severity Scale (YGTSS)Through study completion, an average of 3 months
Tic severity will be measured with YGTSS. YGTSS is a clinician-rated scale used to assess tic severity, scored out of 100 where a higher score indicates greater tic frequency and severity. It includes a checklist of motor and vocal tics followed by an assessment of the number, frequency, intensity, complexity, and inference of motor tics and phonic tics - scored separately. Each of these dimensions is scored on a 0 to 5 scale. The YGTSS provides three tic severity scores: Total Motor (0 to 25); Total Phonic (0 to 25) and the combined Total Tic Severity Score (0 to 50), as well as a separate Impairment dimension scored from 0 to 50.
- Modified Rush Videotape Tic Rating Scale (mRVTRS)Through study completion, an average of 3 months
This is a tool used by an objective examiner to quantify the severity of a patient's tics by rating the number of body areas affected, motor tic frequency, phonic tic frequency, motor tic severity, and phonic tic severity, each on a 0 through 4 score by watching a video of the patient. Scored out of 20, where a higher score indicates greater tic severity.